Abstract：
Rhinosinusitis is one of the most common diseases today. Among diseases requiring treatment with antibiotics, it is the fifth most common. Acute rhinosinusitis is a significant medical problem that can significantly lower quality of life and can cause a large economic impact on society. Herein, we collected and analyzed data from several published studies regarding sinusitis with the aim of creating a sinusitis model. We included data from 786 studies published between 1996 and 2016 that came up on Google, Pro Quest Central or PubMed using the following keywords (or combinations thereof): \"sinusitis\", \"rhinosinusitis\", \"experimental\", \"animal\", \"model\", \"rat\", \"rabbit\", \"guinea pig\" and \"mice\". An appropriate sinusitis model must be established using the correct animal. Thus far, sinusitis models have been published in rats, mice, and rabbits, with rabbits being the most frequently used animal. These animals are used because the anatomy and physiology of their sinuses are very similar to those of humans. While these animals can be used in surgical models, it must be noted that prolonged stress can cause them high mortality rates. Several studies have used strains of Streptococcus pneumoniae to induce rhinosinusitis; however, it has recently been shown that other pathogenic agents can be used for this purpose as well. In this review, we presented several experimental sinusitis models in rats, mice, and rabbits. We hope that by presenting these methods, researchers may be better able to design and perform more useful sinusitis studies.
摘要：
鼻窦炎是当今最常见的疾病之一。在需要抗生素治疗的疾病中，它是第五常见的。急性鼻-鼻窦炎是一个重要的医学问题，可以显着降低生活质量，并可能对社会造成巨大的经济影响。在这里，我们收集并分析了几项已发表的关于鼻窦炎的研究数据,目的是建立鼻窦炎模型.我们纳入了1996年至2016年间发表在Google上的786项研究的数据，ProQuestCentral或PubMed使用以下关键字（或其组合）：“鼻窦炎”，“鼻窦炎”，\"实验性\",\"动物\",\"型号\",\"老鼠\",\"兔子\",“豚鼠”和“老鼠”。必须使用正确的动物建立适当的鼻窦炎模型。到目前为止,鼻窦炎模型已经在大鼠中发表，老鼠,兔子,兔子是最常用的动物。使用这些动物是因为它们的鼻窦的解剖学和生理学与人类非常相似。虽然这些动物可以用于手术模型，必须指出，长期的压力会导致他们的高死亡率。一些研究已经使用肺炎链球菌菌株诱导鼻窦炎;然而，最近已经表明,其它病原体也可以用于该目的。在这次审查中,我们介绍了几种大鼠的实验性鼻窦炎模型，老鼠,还有兔子.我们希望通过介绍这些方法，研究人员可能能够更好地设计和执行更有用的鼻窦炎研究。
