Abstract：
Antibiotic abuse has posed enormous burdens on patients and healthcare systems. Hence, the design and development of non-antibiotic wound dressings to meet clinical demand are urgently desired. However, there remains one of the impediments to hydrogel wound dressings that integrated with good recoverability, toughness, and excellent antibacterial properties. Herein, a series of semi-interpenetrating network (semi-IPN) hydrogels with exceptional mechanical performance and remarkable antibacterial activity based on quaternized chitosan (QCS) and polyacrylamide (PAM) were developed using a one-pot method. Additionally, the antibacterial activity of semi-IPN hydrogel against S. aureus and E. coli was enhanced by integrating it with quercetin (QT). The semi-IPN hydrogels also exhibited high recoverability and toughness, outstanding liquid absorbability (the swelling ratio reached 565 ± 12 %), and a satisfying water vapor transmission rate. Moreover, the semi-IPN hydrogels presented ideal hemocompatibility and cytocompatibility. These high-elastic hydrogels are promising candidates for potential applications in wound dressing, tissue repair, chronic wound care, as well as other biomedical fields.
摘要：
滥用抗生素给患者和医疗保健系统带来了巨大的负担。因此，迫切需要设计和开发非抗生素伤口敷料以满足临床需求。然而,水凝胶伤口敷料具有良好的可恢复性，韧性,和优异的抗菌性能。在这里，使用一锅法开发了一系列基于季铵化壳聚糖（QCS）和聚丙烯酰胺（PAM）的具有出色机械性能和显着抗菌活性的半互穿网络（semi-IPN）水凝胶。此外,半IPN水凝胶与槲皮素（QT）的整合增强了其对金黄色葡萄球菌和大肠杆菌的抗菌活性。半IPN水凝胶还表现出高的可恢复性和韧性，出色的液体吸收性（溶胀率达到565±12％），和令人满意的水蒸气透过率。此外，半IPN水凝胶具有理想的血液相容性和细胞相容性。这些高弹性水凝胶是伤口敷料潜在应用的有希望的候选人，组织修复,慢性伤口护理，以及其他生物医学领域。
