Abstract：
Over the last years, we have learned that the metabolic phenotype of immune cells is closely connected to the cell\'s effector function. Understanding these changes will allow us to better understand allergic disease pathology and improve allergy treatment by modulating immune metabolic pathways. As part two of a two-article series, this review reports on the recent studies investigating the metabolism of the cell types involved in allergies and discusses the initial application of these discoveries in allergy treatment.
The cell types involved in allergic reactions display pronounced and highly specific metabolic changes (here discussed for epithelial cells, APCs, ILC2s, mast cells, eosinophils, and Th2 cells). Currently, the first drugs targeting metabolic pathways are tested for their potential to improve allergy treatment. Immune-metabolic changes observed in allergy so far are complex and depend on the investigated disease and cell type. However, our increased understanding of the underlying principles has pointed to several promising target molecules that are now being investigated to improve allergy treatment.
The cell types involved in allergic reactions display pronounced and highly specific metabolic changes (here discussed for epithelial cells, APCs, ILC2s, mast cells, eosinophils, and Th2 cells). Currently, the first drugs targeting metabolic pathways are tested for their potential to improve allergy treatment. Immune-metabolic changes observed in allergy so far are complex and depend on the investigated disease and cell type. However, our increased understanding of the underlying principles has pointed to several promising target molecules that are now being investigated to improve allergy treatment.
摘要：
目标：在过去的几年中，我们了解到免疫细胞的代谢表型与细胞的效应子功能紧密相关。了解这些变化将使我们更好地了解过敏性疾病的病理学，并通过调节免疫代谢途径来改善过敏治疗。作为两篇文章系列的第二部分，这篇综述报道了最近对涉及过敏的细胞类型代谢的研究，并讨论了这些发现在过敏治疗中的初步应用。
结果：涉及过敏反应的细胞类型显示出明显且高度特异性的代谢变化（这里讨论的是上皮细胞，APC,ILC2s,肥大细胞,嗜酸性粒细胞,和Th2细胞）。目前,首批针对代谢途径的药物被测试其改善过敏治疗的潜力。到目前为止，在过敏中观察到的免疫代谢变化是复杂的，并且取决于所研究的疾病和细胞类型。然而,我们对基本原理的理解越来越多,这表明目前正在研究几种有前景的靶分子来改善过敏治疗.
结果：涉及过敏反应的细胞类型显示出明显且高度特异性的代谢变化（这里讨论的是上皮细胞，APC,ILC2s,肥大细胞,嗜酸性粒细胞,和Th2细胞）。目前,首批针对代谢途径的药物被测试其改善过敏治疗的潜力。到目前为止，在过敏中观察到的免疫代谢变化是复杂的，并且取决于所研究的疾病和细胞类型。然而,我们对基本原理的理解越来越多,这表明目前正在研究几种有前景的靶分子来改善过敏治疗.
