PDF(Pubmed)
Abstract：
UNASSIGNED: Cocaine use is a well-established risk factor for acute coronary syndrome (ACS) although other recreational drugs (RD), are increasingly considered as potential cardiac risk factors. Compared to ACS without RD use, worse outcomes have been described for RD-associated ACS.
UNASSIGNED: The aim of this study was to explore the use of RD in a contemporary cohort of young ACS patients.
UNASSIGNED: Between June 2016 and October 2019, ACS patients aged 18-50 years, admitted to OLVG Hospital in Amsterdam, were retrospectively analysed. Medical chart review was performed to obtain patient and clinical characteristics, RD use, cardiac risk factors, outcome and follow up.
UNASSIGNED: A total of 229 patients were included in the study. Recreational drug use prior to ACS was present in 24.9% of all patients, with cannabis (16.2%), cocaine (4.8%), or both (2.6%) most commonly observed. RD users were predominantly young men (87.7%) and had a significantly higher tobacco use compared to non-RD users (89.5% vs. 62.8%, P < 0.001), also after adjusting for age and sex. RD use was associated with larger myocardial infarctions with significantly higher CK-MB levels (104 ± 116 U/L vs 62 ± 96, P = 0.040) and poorer left ventricular function measured by echocardiography as compared to non-users (P = 0.007).
UNASSIGNED: Recreational drug use was present in almost 25% of all young ACS patients evaluated for drug use and was associated with larger myocardial infarction resulting in poorer left ventricular function as compared to non-users. Additionally, RD-users were younger and were more often tobacco users, compared to non-users.
UNASSIGNED: The aim of this study was to explore the use of RD in a contemporary cohort of young ACS patients.
UNASSIGNED: Between June 2016 and October 2019, ACS patients aged 18-50 years, admitted to OLVG Hospital in Amsterdam, were retrospectively analysed. Medical chart review was performed to obtain patient and clinical characteristics, RD use, cardiac risk factors, outcome and follow up.
UNASSIGNED: A total of 229 patients were included in the study. Recreational drug use prior to ACS was present in 24.9% of all patients, with cannabis (16.2%), cocaine (4.8%), or both (2.6%) most commonly observed. RD users were predominantly young men (87.7%) and had a significantly higher tobacco use compared to non-RD users (89.5% vs. 62.8%, P < 0.001), also after adjusting for age and sex. RD use was associated with larger myocardial infarctions with significantly higher CK-MB levels (104 ± 116 U/L vs 62 ± 96, P = 0.040) and poorer left ventricular function measured by echocardiography as compared to non-users (P = 0.007).
UNASSIGNED: Recreational drug use was present in almost 25% of all young ACS patients evaluated for drug use and was associated with larger myocardial infarction resulting in poorer left ventricular function as compared to non-users. Additionally, RD-users were younger and were more often tobacco users, compared to non-users.
摘要：
未经证实：可卡因的使用是急性冠状动脉综合征（ACS）的公认危险因素，尽管其他娱乐性药物（RD），越来越被认为是潜在的心脏危险因素。与不使用RD的ACS相比，RD相关ACS的结局较差.
UNASSIGNED：本研究的目的是探索RD在当代年轻ACS患者队列中的应用。
未经评估：2016年6月至2019年10月，年龄18-50岁的ACS患者，住在阿姆斯特丹的OLVG医院,进行了回顾性分析。进行病历审查以获得患者和临床特征，RD使用,心脏危险因素,结果和后续行动。
未经证实：共229名患者纳入研究。所有患者中有24.9%出现ACS前的娱乐性药物使用，大麻（16.2%），可卡因(4.8%),或两者（2.6％）最常见的观察。RD使用者主要是年轻男性（87.7％），与非RD使用者相比，烟草使用量明显更高（89.5％与62.8%,P<0.001)，在调整了年龄和性别之后。与非使用者相比，使用RD与更大的心肌梗塞相关，CK-MB水平明显更高（104±116U/Lvs62±96，P=0.040），超声心动图测得的左心室功能较差（P=0.007）。
UNASSIGNED：在接受药物使用评估的所有年轻ACS患者中，近25%的患者使用娱乐性药物，与未使用者相比，与更大的心肌梗死相关，导致左心室功能更差。此外,RD使用者更年轻，更经常是烟草使用者，与非用户相比。
UNASSIGNED：本研究的目的是探索RD在当代年轻ACS患者队列中的应用。
未经评估：2016年6月至2019年10月，年龄18-50岁的ACS患者，住在阿姆斯特丹的OLVG医院,进行了回顾性分析。进行病历审查以获得患者和临床特征，RD使用,心脏危险因素,结果和后续行动。
未经证实：共229名患者纳入研究。所有患者中有24.9%出现ACS前的娱乐性药物使用，大麻（16.2%），可卡因(4.8%),或两者（2.6％）最常见的观察。RD使用者主要是年轻男性（87.7％），与非RD使用者相比，烟草使用量明显更高（89.5％与62.8%,P<0.001)，在调整了年龄和性别之后。与非使用者相比，使用RD与更大的心肌梗塞相关，CK-MB水平明显更高（104±116U/Lvs62±96，P=0.040），超声心动图测得的左心室功能较差（P=0.007）。
UNASSIGNED：在接受药物使用评估的所有年轻ACS患者中，近25%的患者使用娱乐性药物，与未使用者相比，与更大的心肌梗死相关，导致左心室功能更差。此外,RD使用者更年轻，更经常是烟草使用者，与非用户相比。
