We used an evidence-based, operational definition of personal utility, with data from a systematic literature review and Delphi survey to build a novel scale. After piloting with 24 adults, the PrU was administered to healthy adults in a Clinical Sequencing Evidence-Generating Research Consortium study after receiving results. We investigated the responses using exploratory factor analysis.
The exploratory factor analysis (N = 841 participants) resulted in a 3-factor solution, accounting for 74% of the variance in items: (1) self-knowledge (α = 0.92), (2) reproductive planning (α = 0.89), and (3) practical benefits (α = 0.91).
Our findings support the use of the 3-factor PrU to assess personal utility of genomic results. Validation of the PrU in other samples will be important for more wide-spread application.
方法:我们使用了基于证据的方法,个人效用的操作定义,用系统的文献综述和德尔菲调查的数据构建了一个新的量表。在与24名成年人一起驾驶后,在一项临床测序证据产生研究联盟(CSER)研究中,在获得结果后,对健康成人进行了PrU给药.我们使用探索性因子分析调查了反应。
结果:探索性因素分析(n=841名参与者)得出了三因素解决方案,占项目差异的74%:1)自我知识(α=0.92),2)生殖计划(α=.89),3)实际效益(α=.91)。
结论:我们的发现支持使用三因子PrU来评估基因组结果的个人效用。在其他样品中验证PrU对于更广泛的应用将是重要的。