Abstract：
To assess the reliability of different salivary biomarkers as skeletal maturity indicators when compared with other methods of skeletal maturity assessment.
A comprehensive search was conducted on three electronic databases: PUBMED, Google scholar and Cochrane library for the articles published from 2000 to July 2021. Assessment of skeletal age on the basis of levels of different salivary biomarkers at different pubertal stages was considered as the primary outcome. Electronic search, data collection and risk of bias assessment were performed by two authors with conflict resolution by the third author.
Total 158 articles were retrieved after screening of titles, abstracts and full texts of all articles, of which 15 articles were selected for qualitative synthesis. All these studies were cross-sectional in design. These studies compared the levels of different salivary biomarkers as Alkaline Phosphatase (ALP), Insulin-like Growth Factor - I (IGF-I), Insulin-like Growth Factor Binding Protein-3 (IGFBP-3), Cortisol, Indian Hedgehog (IHH) protein and Dehydroepiandrosterone sulphate (DHEAS) with other methods of skeletal age estimation. Out of these six biomarkers salivary IGF-1 is a reliable indicator for skeletal maturity assessment.
The current evidence suggests that salivary biomarkers can be used as an adjunct for growth prediction during orthodontic treatment planning along with other methods of skeletal maturation assessment. Still there is need for further research with longitudinal studies in this field.
A comprehensive search was conducted on three electronic databases: PUBMED, Google scholar and Cochrane library for the articles published from 2000 to July 2021. Assessment of skeletal age on the basis of levels of different salivary biomarkers at different pubertal stages was considered as the primary outcome. Electronic search, data collection and risk of bias assessment were performed by two authors with conflict resolution by the third author.
Total 158 articles were retrieved after screening of titles, abstracts and full texts of all articles, of which 15 articles were selected for qualitative synthesis. All these studies were cross-sectional in design. These studies compared the levels of different salivary biomarkers as Alkaline Phosphatase (ALP), Insulin-like Growth Factor - I (IGF-I), Insulin-like Growth Factor Binding Protein-3 (IGFBP-3), Cortisol, Indian Hedgehog (IHH) protein and Dehydroepiandrosterone sulphate (DHEAS) with other methods of skeletal age estimation. Out of these six biomarkers salivary IGF-1 is a reliable indicator for skeletal maturity assessment.
The current evidence suggests that salivary biomarkers can be used as an adjunct for growth prediction during orthodontic treatment planning along with other methods of skeletal maturation assessment. Still there is need for further research with longitudinal studies in this field.
摘要：
目的：与其他骨骼成熟度评估方法相比，评估不同唾液生物标志物作为骨骼成熟度指标的可靠性。
方法：对三个电子数据库进行了全面搜索：PUBMED，Google学者和Cochrane图书馆为2000年至2021年7月发表的文章。根据不同青春期不同唾液生物标志物水平评估骨骼年龄被认为是主要结果。电子搜索,数据收集和偏倚风险评估由两名作者进行,第三作者解决了冲突.
结果：标题筛选后，共检索到158篇文章，所有文章的摘要和全文，其中选取15篇文章进行定性综合。所有这些研究都是横截面设计。这些研究比较了不同唾液生物标志物的水平，如碱性磷酸酶（ALP），胰岛素样生长因子-I(IGF-I),胰岛素样生长因子结合蛋白-3(IGFBP-3),皮质醇,印度刺猬（IHH）蛋白和硫酸脱氢表雄酮（DHEAS）与其他方法的骨骼年龄估计。在这六种生物标志物中，唾液IGF-1是骨骼成熟度评估的可靠指标。
结论：目前的证据表明，唾液生物标志物可以用作正畸治疗计划期间生长预测的辅助手段以及其他骨骼成熟度评估方法。在这一领域还需要进一步的纵向研究。
方法：对三个电子数据库进行了全面搜索：PUBMED，Google学者和Cochrane图书馆为2000年至2021年7月发表的文章。根据不同青春期不同唾液生物标志物水平评估骨骼年龄被认为是主要结果。电子搜索,数据收集和偏倚风险评估由两名作者进行,第三作者解决了冲突.
结果：标题筛选后，共检索到158篇文章，所有文章的摘要和全文，其中选取15篇文章进行定性综合。所有这些研究都是横截面设计。这些研究比较了不同唾液生物标志物的水平，如碱性磷酸酶（ALP），胰岛素样生长因子-I(IGF-I),胰岛素样生长因子结合蛋白-3(IGFBP-3),皮质醇,印度刺猬（IHH）蛋白和硫酸脱氢表雄酮（DHEAS）与其他方法的骨骼年龄估计。在这六种生物标志物中，唾液IGF-1是骨骼成熟度评估的可靠指标。
结论：目前的证据表明，唾液生物标志物可以用作正畸治疗计划期间生长预测的辅助手段以及其他骨骼成熟度评估方法。在这一领域还需要进一步的纵向研究。
