Abstract：
The synergism between thermoresponsive and bioadhesive polymers can lead to the optimization of materials with enhanced mechanical and bioadhesive properties. Quality by Design can assure the understanding and control of formulation variables. In this approach, Design of Experiment has been widely utilized as an important strategy. Poly(methyl vinyl ether-alt-maleic anhydride) (PVMMA) is a bioadhesive polymer and Pluronic F127 (PF127) shows thermoresponsiveness. The association of these two polymers has been poorly investigated. The aim of this work was to study the mechanical, bioadhesive and rheological properties of polymer mixtures composed of PVMMA and PF127, in order to select the best conditions and formulations for biomedical applications. Textural properties (hardness, compressibility, adhesiveness, cohesiveness and elasticity), softness index, bioadhesion and rheological characteristics (flow and viscoelasticity) showed that 17.5-20% (w/w) PF127-polymer mixtures displayed improved values of the parameters. However, the rheological interaction parameter showed low synergism, due to the polymers\' characteristics and system organization. The formulations displayed gelation temperatures suitable for administration, with improved bioadhesive properties mainly at 34 °C and suggests the formulations can be used for biomedical applications. DoE constituted an important tool to investigate these systems showing the main effects that significantly influence the binary mixtures.
摘要：
热响应性和生物粘附性聚合物之间的协同作用可以导致具有增强的机械和生物粘附性的材料的优化。设计质量可以确保对配方变量的理解和控制。在这种方法中，实验设计已被广泛用作一种重要策略。聚（甲基乙烯基醚-alt-马来酸酐）（PVMMA）是一种生物粘附聚合物，PluronicF127（PF127）显示出热响应性。对这两种聚合物的缔合研究甚少。这项工作的目的是研究机械，由PVMMA和PF127组成的聚合物混合物的生物粘附性和流变性能，以便为生物医学应用选择最佳条件和配方。纹理特性(硬度、可压缩性,粘附性,粘结性和弹性)，柔软度指数,生物粘附和流变特性（流动和粘弹性）表明，17.5-20％（w/w）PF127-聚合物混合物显示出改善的参数值。然而,流变相互作用参数显示出低协同作用，由于聚合物的特性和系统组织。该制剂显示出适合给药的胶凝温度，主要在34°C下具有改善的生物粘附性能，并表明该制剂可用于生物医学应用。DoE构成了研究这些系统的重要工具，这些系统显示了显着影响二元混合物的主要作用。
