Abstract：
Studies have shown poor correlation between intra-cardiac pressures and blood volume (BV) measurements including HF. The impact of sex and left ventricular ejection fraction (LVEF) on this relationship has not been studied. We obtained pressure (pulmonary artery diastolic pressure (PADP)) and volume (total blood volume (TBV) and estimated stress blood volume (eSBV)) measurements from HF patients at the time of CardioMEMS implantation. A total of 20 patients were included. There was no significant difference between PADP, TBV, and eSBV between sexes. There was only a moderate correlation between PADP and eSBV in men but not in women or with TBV in both sexes. HFrEF had higher PADP and eSBV than HFpEF. There was a consistent lack of correlation between PADP and both TBV and eSBV. Further studies evaluating mid- to long-term implications of pressure-volume profiles as well as changes following decongestion therapy are warranted to better understand the pressure-volume interplay and determine appropriate decongestion strategy for each pressure-volume phenotype.
摘要：
研究表明，心脏内压和包括HF在内的血容量（BV）测量值之间的相关性较差。性别和左心室射血分数（LVEF）对这种关系的影响尚未研究。我们在CardioMEMS植入时获得了HF患者的压力（肺动脉舒张压（PADP））和体积（总血容量（TBV）和估计的压力血容量（eSBV））测量值。共纳入20例患者。PADP之间无显著差异，TBV,和性别之间的eSBV。男性的PADP和eSBV之间仅存在中度相关性，而女性则没有，两性的TBV也没有。HFrEF的PADP和eSBV高于HFpEF。PADP与TBV和eSBV之间始终缺乏相关性。需要进一步研究评估压力-体积曲线的中长期影响以及减充血治疗后的变化，以更好地了解压力-体积相互作用并确定每种压力-体积表型的适当减充血策略。
