PDF(Pubmed)
Abstract：
Disseminated peritoneal leiomyomatosis (DPL) is a benign metastasis of leiomyoma mimicking metastasis of malignancy. It usually affects premenopausal women. Malignant transformation is a rare clinical scenario of DPL. However, its etiology is unknown with unusual growth patterns, either of which makes the diagnosis difficult. It was postulated that the pathophysiology of DPL is metaplasia of mesothelial cells under the effect of hormonal stimulation. Hence, we reported the case of a 62-year-old woman with a history of left breast cancer, who presented with DPL and metastasis to the lung with malignant transformation after two years of starting prophylactic tamoxifen therapy. The influence of tamoxifen use on the development of DPL is not fully understood; this is a rare case that highlights a possible association between tamoxifen and the malignancy transformation of DPL. Hence, it may help raise awareness among clinicians dealing with women using tamoxifen or other hormonal therapy, and the risk of DPL development with potential malignant transformation in such patients.
摘要：
播散性腹膜平滑肌瘤病（DPL）是平滑肌瘤的良性转移，模仿恶性肿瘤的转移。它通常影响绝经前妇女。恶性转化是DPL的罕见临床情形。然而,其病因不明，生长模式异常，任何一种都使诊断变得困难。据推测，DPL的病理生理学是在激素刺激的作用下间皮细胞的化生。因此，我们报道了一名62岁的女性，有左乳腺癌病史，开始预防性他莫昔芬治疗两年后，出现DPL并转移到肺部并伴有恶变。使用他莫昔芬对DPL发展的影响尚未完全了解；这是一种罕见的情况，突显了他莫昔芬与DPL恶性转化之间的可能关联。因此，它可能有助于提高临床医生对使用他莫昔芬或其他激素治疗的女性的认识，以及此类患者发生DPL并伴有潜在恶变的风险。
