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Abstract：
Calcitonin (Ct)-negative medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor. This study aimed to clarify its incidence, clinicopathologic characteristics, management, and treatment outcome.
We retrospectively analyzed data of patients with primary MTC. Patients were divided into two groups according to the preoperative serum Ct level (Ct-negative and Ct-positive). The demographic, pathologic, and molecular characteristics, and treatment outcomes were compared between the two groups. In the Ct-negative group, we analyzed the association between the operation type and treatment outcome.
Of the total 312 patients, 24 were diagnosed with Ct-negative MTC. The rate of lymph node metastasis was significantly higher in the Ct-positive than in the Ct-negative group (47.9% vs. 0%, p<0.001). The proportion of patients with Ki-67 ≤10% was significantly higher in the Ct-negative than in the Ct-positive group (87.5% vs. 38.2%, p<0.001). Excellent response was achieved by 91.7% and 34.7% of patients in the Ct-negative and Ct-positive groups, respectively (p<0.001). In the Ct-negative group, excellent response was achieved by all female patients, but only 50% of male patients.
Ct-negative MTC is rare and unlikely to develop lymph node metastasis. Unilateral lobectomy tends to provide a satisfactory chance of excellent response; however, this requires further validation.
We retrospectively analyzed data of patients with primary MTC. Patients were divided into two groups according to the preoperative serum Ct level (Ct-negative and Ct-positive). The demographic, pathologic, and molecular characteristics, and treatment outcomes were compared between the two groups. In the Ct-negative group, we analyzed the association between the operation type and treatment outcome.
Of the total 312 patients, 24 were diagnosed with Ct-negative MTC. The rate of lymph node metastasis was significantly higher in the Ct-positive than in the Ct-negative group (47.9% vs. 0%, p<0.001). The proportion of patients with Ki-67 ≤10% was significantly higher in the Ct-negative than in the Ct-positive group (87.5% vs. 38.2%, p<0.001). Excellent response was achieved by 91.7% and 34.7% of patients in the Ct-negative and Ct-positive groups, respectively (p<0.001). In the Ct-negative group, excellent response was achieved by all female patients, but only 50% of male patients.
Ct-negative MTC is rare and unlikely to develop lymph node metastasis. Unilateral lobectomy tends to provide a satisfactory chance of excellent response; however, this requires further validation.
摘要：
未经证实：降钙素（Ct）阴性的甲状腺髓样癌（MTC）是一种罕见的神经内分泌肿瘤。本研究旨在阐明其发病率，临床病理特征，管理,和治疗结果。
UNASSIGNED：我们回顾性分析了原发性MTC患者的资料。根据术前血清Ct水平将患者分为两组（Ct阴性和Ct阳性）。人口统计，病理性,和分子特征，比较两组的治疗效果。在Ct阴性组中，我们分析了手术类型与治疗结果之间的相关性.
未经批准：在总共312名患者中，24例诊断为Ct阴性MTC。Ct阳性组的淋巴结转移率明显高于Ct阴性组（47.9％vs.0%,p<0.001)。Ct阴性组Ki-67≤10%的患者比例明显高于Ct阳性组(87.5%vs.38.2%,p<0.001)。在Ct阴性和Ct阳性组中，91.7％和34.7％的患者达到了良好的反应，分别(p<0.001)。在Ct阴性组中，所有女性患者均获得了出色的反应，但只有50%的男性患者。
UNASSIGNED：Ct阴性MTC是罕见的，不太可能发生淋巴结转移。单侧肺叶切除术往往会提供令人满意的良好反应机会；然而，这需要进一步验证。
UNASSIGNED：我们回顾性分析了原发性MTC患者的资料。根据术前血清Ct水平将患者分为两组（Ct阴性和Ct阳性）。人口统计，病理性,和分子特征，比较两组的治疗效果。在Ct阴性组中，我们分析了手术类型与治疗结果之间的相关性.
未经批准：在总共312名患者中，24例诊断为Ct阴性MTC。Ct阳性组的淋巴结转移率明显高于Ct阴性组（47.9％vs.0%,p<0.001)。Ct阴性组Ki-67≤10%的患者比例明显高于Ct阳性组(87.5%vs.38.2%,p<0.001)。在Ct阴性和Ct阳性组中，91.7％和34.7％的患者达到了良好的反应，分别(p<0.001)。在Ct阴性组中，所有女性患者均获得了出色的反应，但只有50%的男性患者。
UNASSIGNED：Ct阴性MTC是罕见的，不太可能发生淋巴结转移。单侧肺叶切除术往往会提供令人满意的良好反应机会；然而，这需要进一步验证。
