We retrospectively analyzed data of patients with primary MTC. Patients were divided into two groups according to the preoperative serum Ct level (Ct-negative and Ct-positive). The demographic, pathologic, and molecular characteristics, and treatment outcomes were compared between the two groups. In the Ct-negative group, we analyzed the association between the operation type and treatment outcome.
Of the total 312 patients, 24 were diagnosed with Ct-negative MTC. The rate of lymph node metastasis was significantly higher in the Ct-positive than in the Ct-negative group (47.9% vs. 0%, p<0.001). The proportion of patients with Ki-67 ≤10% was significantly higher in the Ct-negative than in the Ct-positive group (87.5% vs. 38.2%, p<0.001). Excellent response was achieved by 91.7% and 34.7% of patients in the Ct-negative and Ct-positive groups, respectively (p<0.001). In the Ct-negative group, excellent response was achieved by all female patients, but only 50% of male patients.
Ct-negative MTC is rare and unlikely to develop lymph node metastasis. Unilateral lobectomy tends to provide a satisfactory chance of excellent response; however, this requires further validation.
UNASSIGNED:我们回顾性分析了原发性MTC患者的资料。根据术前血清Ct水平将患者分为两组(Ct阴性和Ct阳性)。人口统计,病理性,和分子特征,比较两组的治疗效果。在Ct阴性组中,我们分析了手术类型与治疗结果之间的相关性.
未经批准:在总共312名患者中,24例诊断为Ct阴性MTC。Ct阳性组的淋巴结转移率明显高于Ct阴性组(47.9%vs.0%,p<0.001)。Ct阴性组Ki-67≤10%的患者比例明显高于Ct阳性组(87.5%vs.38.2%,p<0.001)。在Ct阴性和Ct阳性组中,91.7%和34.7%的患者达到了良好的反应,分别(p<0.001)。在Ct阴性组中,所有女性患者均获得了出色的反应,但只有50%的男性患者。
UNASSIGNED:Ct阴性MTC是罕见的,不太可能发生淋巴结转移。单侧肺叶切除术往往会提供令人满意的良好反应机会;然而,这需要进一步验证。