PDF(Pubmed)
Abstract：
The main treatment for bacterial infections is antibiotic therapy, but the emergence of bacterial resistance has severely limited the efficacy of antibiotics. Therefore, another effective means of treating bacterial infections is needed to alleviate the therapeutic pressure caused by antibiotic resistance. Photodynamic antibacterial therapy (PDAT) has gradually entered people\'s field of vision as an infection treatment method that does not depend on antibiotics. PDAT induces photosensitizers (PS) to produce reactive oxygen species (ROS) under light irradiation, and kills bacteria by destroying biological macromolecules at bacterial infection sites. In recent years, researchers have found that some nanomaterials delivering PS can improve PDAT through targeted delivery or synergistic therapeutic effect. Therefore, in this article, we will review the recent applications of several nanomaterials in PDAT, including metal nanoclusters, metal-organic frameworks, and other organic/inorganic nanoparticles, and discuss the advantages and disadvantage of these nanomaterials as carriers for delivery PS to further advance the development of PDAT.
摘要：
细菌感染的主要治疗方法是抗生素治疗，但是细菌耐药性的出现严重限制了抗生素的疗效。因此,治疗细菌感染的另一种有效方法是需要减轻抗生素耐药性造成的治疗压力。光动力抗菌疗法(PDAT)作为一种不依赖抗生素的感染治疗方法,逐渐进入人们的视野。PDAT诱导光敏剂（PS）在光照下产生活性氧（ROS），并通过破坏细菌感染部位的生物大分子来杀死细菌。近年来,研究人员发现，一些递送PS的纳米材料可以通过靶向递送或协同治疗作用改善PDAT。因此,在这篇文章中,我们将回顾几种纳米材料在PDAT中的最新应用，包括金属纳米团簇，金属有机框架，和其他有机/无机纳米粒子，并讨论了这些纳米材料作为递送PS载体的优缺点，以进一步推进PDAT的发展。
