PDF(Pubmed)
Abstract：
BACKGROUND: Coronavirus disease 2019 (COVID-19) has rapidly spread worldwide, causing widespread mortality. Many patients with COVID-19 have been treated in homes, hotels, and medium-sized hospitals where doctors were responsible for assessing the need for critical care hospitalization. This study aimed to establish a severity prediction score for critical care triage.
METHODS: We analyzed the data of 368 patients with mild-to-moderate COVID-19 who had been admitted to Fussa Hospital, Japan, from April 2020 to February 2022. We defined a high-oxygen group as requiring ≥4 l/min of oxygen. Multivariable logistic regression was used to construct a risk prediction score, and the best model was selected using a stepwise selection method.
RESULTS: Multivariable analysis showed that older age (≥70 years), elevated creatine kinase (≥127 U/L), C-reactive protein (≥2.19 mg/dL), and ferritin (≥632.7 ng/mL) levels were independent risk factors associated with the high-oxygen group. Each risk factor was assigned a score ranging from 0 to 4, and we referred to the final overall score as the Fussa score. Patients were classified into two groups, namely, high-risk (total risk factors, ≥2) and low-risk (total risk score, <2) groups. The high-risk group had a significantly worse prognosis (low-risk group, undefined vs. high-risk group, undefined; P< 0.0001).
CONCLUSIONS: The Fussa score might help to identify patients with COVID-19 who require critical care hospitalization.
METHODS: We analyzed the data of 368 patients with mild-to-moderate COVID-19 who had been admitted to Fussa Hospital, Japan, from April 2020 to February 2022. We defined a high-oxygen group as requiring ≥4 l/min of oxygen. Multivariable logistic regression was used to construct a risk prediction score, and the best model was selected using a stepwise selection method.
RESULTS: Multivariable analysis showed that older age (≥70 years), elevated creatine kinase (≥127 U/L), C-reactive protein (≥2.19 mg/dL), and ferritin (≥632.7 ng/mL) levels were independent risk factors associated with the high-oxygen group. Each risk factor was assigned a score ranging from 0 to 4, and we referred to the final overall score as the Fussa score. Patients were classified into two groups, namely, high-risk (total risk factors, ≥2) and low-risk (total risk score, <2) groups. The high-risk group had a significantly worse prognosis (low-risk group, undefined vs. high-risk group, undefined; P< 0.0001).
CONCLUSIONS: The Fussa score might help to identify patients with COVID-19 who require critical care hospitalization.
摘要：
背景：2019年冠状病毒病（COVID-19）在全球范围内迅速传播，造成广泛的死亡率。许多COVID-19患者已经在家中接受了治疗，酒店,以及由医生负责评估重症监护住院需求的中型医院。本研究旨在建立重症监护分诊的严重程度预测评分。
方法：我们分析了Fussa医院收治的368例轻中度COVID-19患者的数据，Japan,从2020年4月到2022年2月。我们将高氧基团定义为需要≥4l/min的氧气。多变量逻辑回归用于构建风险预测评分，并使用逐步选择方法选择最佳模型。
结果：多变量分析表明，年龄较大（≥70岁），肌酸激酶升高（≥127U/L），C反应蛋白（≥2.19mg/dL），和铁蛋白(≥632.7ng/mL)水平是与高氧组相关的独立危险因素.每个风险因素的评分范围为0到4，我们将最终的总分称为Fussa评分。患者分为两组，即,高风险(总风险因素，≥2)和低风险(总风险评分，<2）组。高风险组的预后明显较差（低风险组，未定义vs.高危人群,未定义；P<0.0001)。
结论：Fussa评分可能有助于识别需要重症监护住院的COVID-19患者。
方法：我们分析了Fussa医院收治的368例轻中度COVID-19患者的数据，Japan,从2020年4月到2022年2月。我们将高氧基团定义为需要≥4l/min的氧气。多变量逻辑回归用于构建风险预测评分，并使用逐步选择方法选择最佳模型。
结果：多变量分析表明，年龄较大（≥70岁），肌酸激酶升高（≥127U/L），C反应蛋白（≥2.19mg/dL），和铁蛋白(≥632.7ng/mL)水平是与高氧组相关的独立危险因素.每个风险因素的评分范围为0到4，我们将最终的总分称为Fussa评分。患者分为两组，即,高风险(总风险因素，≥2)和低风险(总风险评分，<2）组。高风险组的预后明显较差（低风险组，未定义vs.高危人群,未定义；P<0.0001)。
结论：Fussa评分可能有助于识别需要重症监护住院的COVID-19患者。
