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Abstract：
UNASSIGNED: This study aimed to investigate multi-trajectories of systolic and diastolic hypertension and assess their association with the risk of coronary heart disease (CHD) in middle-aged and older Chinese adults.
UNASSIGNED: The study cohort comprised 4,102 individuals aged 40-75 years with records of at least four systolic blood pressure (SBP) and diastolic blood pressure (DBP). A group-based multi-trajectory model was adopted to identify multi-trajectories of systolic and diastolic hypertension, followed by a logistic model to assess the independent associations between these trajectories and CHD risk. The multinomial logistic model was used to evaluate the impact of baseline covariates on trajectory groups.
UNASSIGNED: Six distinct trajectories for systolic and diastolic hypertension were identified which represent distinct stages of hypertension and were characterized as low-stable, low-increasing, medium-decreasing, medium-increasing-decreasing, isolated systolic hypertension phase, and high-decreasing. Compared with the low-stable group, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were 2.23 (1.34-3.70) for the medium-increasing-decreasing group and 1.87 (1.12-3.11) for the high-decreasing group after adjustment for baseline covariates. Compared with the low-increasing group, the ORs and 95% CIs were 1.88 (1.06-3.31) for the medium-increasing-decreasing group. Age, gender, drinking, body mass index (BMI), triglyceride (TG), and fasting plasma glucose (FPG) were independent predictors for trajectory groups 4 and 6.
UNASSIGNED: Novel, clinically defined multi-trajectories of systolic and diastolic hypertension were identified. Middle-aged and older adults with medium-increasing-decreasing or high-decreasing blood pressure trajectories are potentially critical periods for the development of CHD. Preventing adverse changes in hypertension status and reducing the high risk of CHD is necessary for people in distinct trajectory groups.
UNASSIGNED: The study cohort comprised 4,102 individuals aged 40-75 years with records of at least four systolic blood pressure (SBP) and diastolic blood pressure (DBP). A group-based multi-trajectory model was adopted to identify multi-trajectories of systolic and diastolic hypertension, followed by a logistic model to assess the independent associations between these trajectories and CHD risk. The multinomial logistic model was used to evaluate the impact of baseline covariates on trajectory groups.
UNASSIGNED: Six distinct trajectories for systolic and diastolic hypertension were identified which represent distinct stages of hypertension and were characterized as low-stable, low-increasing, medium-decreasing, medium-increasing-decreasing, isolated systolic hypertension phase, and high-decreasing. Compared with the low-stable group, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were 2.23 (1.34-3.70) for the medium-increasing-decreasing group and 1.87 (1.12-3.11) for the high-decreasing group after adjustment for baseline covariates. Compared with the low-increasing group, the ORs and 95% CIs were 1.88 (1.06-3.31) for the medium-increasing-decreasing group. Age, gender, drinking, body mass index (BMI), triglyceride (TG), and fasting plasma glucose (FPG) were independent predictors for trajectory groups 4 and 6.
UNASSIGNED: Novel, clinically defined multi-trajectories of systolic and diastolic hypertension were identified. Middle-aged and older adults with medium-increasing-decreasing or high-decreasing blood pressure trajectories are potentially critical periods for the development of CHD. Preventing adverse changes in hypertension status and reducing the high risk of CHD is necessary for people in distinct trajectory groups.
摘要：
UNASSIGNED：本研究旨在调查中国中老年人收缩期和舒张期高血压的多轨迹，并评估其与冠心病（CHD）风险的关系。
UNASSIGNED：该研究队列包括4,102名年龄在40-75岁之间的个体，记录至少有四个收缩压（SBP）和舒张压（DBP）。采用基于群体的多轨迹模型来识别收缩期和舒张期高血压的多轨迹，其次是一个逻辑模型来评估这些轨迹和CHD风险之间的独立关联。多项逻辑模型用于评估基线协变量对轨迹组的影响。
UNASSIGNED：确定了收缩期和舒张期高血压的六个不同轨迹，这些轨迹代表了高血压的不同阶段，并被表征为低稳定，低增长，中等递减，中等增加减少，单纯收缩期高血压,高下降。与低稳定组相比，校正基线协变量后,中增减组的校正比值比(ORs)和95%置信区间(CIs)分别为2.23(1.34~3.70)和高降组的1.87(1.12~3.11).与低增长组相比，中等增加-减少组的OR和95%CI为1.88(1.06-3.31).年龄,性别,饮酒,体重指数（BMI），甘油三酯（TG），和空腹血糖（FPG）是轨迹组4和6的独立预测因子。
未经批准：小说，确定了临床定义的收缩期和舒张期高血压的多轨迹.具有中等增加-降低或高度降低的血压轨迹的中年和老年人是CHD发展的潜在关键时期。对于不同轨迹组的人来说，预防高血压状态的不良变化和降低冠心病的高风险是必要的。
UNASSIGNED：该研究队列包括4,102名年龄在40-75岁之间的个体，记录至少有四个收缩压（SBP）和舒张压（DBP）。采用基于群体的多轨迹模型来识别收缩期和舒张期高血压的多轨迹，其次是一个逻辑模型来评估这些轨迹和CHD风险之间的独立关联。多项逻辑模型用于评估基线协变量对轨迹组的影响。
UNASSIGNED：确定了收缩期和舒张期高血压的六个不同轨迹，这些轨迹代表了高血压的不同阶段，并被表征为低稳定，低增长，中等递减，中等增加减少，单纯收缩期高血压,高下降。与低稳定组相比，校正基线协变量后,中增减组的校正比值比(ORs)和95%置信区间(CIs)分别为2.23(1.34~3.70)和高降组的1.87(1.12~3.11).与低增长组相比，中等增加-减少组的OR和95%CI为1.88(1.06-3.31).年龄,性别,饮酒,体重指数（BMI），甘油三酯（TG），和空腹血糖（FPG）是轨迹组4和6的独立预测因子。
未经批准：小说，确定了临床定义的收缩期和舒张期高血压的多轨迹.具有中等增加-降低或高度降低的血压轨迹的中年和老年人是CHD发展的潜在关键时期。对于不同轨迹组的人来说，预防高血压状态的不良变化和降低冠心病的高风险是必要的。
