Abstract：
The use of light-emitting diodes (LEDs) has increased considerably in the 21st century with humans living in a modern photoperiod with brighter nights and dimmer days. Prolonged exposure to LEDs, especially at night, is considered a new source of pollution because it may affect the synthesis and secretion of retinal melatonin and dopamine, resulting in negative impacts on retinal circadian clocks and potentially disrupting retinal circadian rhythms. The control of ocular refraction is believed to be related to retinal circadian rhythms. Moreover, the global prevalence of myopia has increased at an alarming rate in recent decades. The widespread use of LEDs and the rapid increase in the prevalence of myopia overlap, which is unlikely to be a coincidence. The connection among LEDs, retinal circadian rhythms, and refractive development is both fascinating and confusing. In this review, we aim to develop a systematic framework that includes LEDs, retinal circadian rhythms and refractive development. This paper summarizes the possible mechanisms by which LEDs may disrupt retinal circadian rhythms. We propose that prolonged exposure to LEDs may induce myopia by disrupting retinal circadian rhythms. Finally, we suggest several possible countermeasures to prevent LED interference on retinal circadian rhythms, with the hope of reducing the onset and progression of myopia.
摘要：
在21世纪，发光二极管（LED）的使用已大大增加，人类生活在现代光周期中，夜晚更明亮，白天更暗。长时间接触发光二极管，尤其是在晚上,被认为是一种新的污染源，因为它可能会影响视网膜褪黑素和多巴胺的合成和分泌，导致对视网膜昼夜节律的负面影响，并可能破坏视网膜昼夜节律。眼屈光的控制被认为与视网膜昼夜节律有关。此外，近几十年来，全球近视患病率以惊人的速度增长。LED的广泛使用和近视患病率的迅速增加重叠,这不太可能是巧合.LED之间的连接，视网膜昼夜节律,屈光发展既令人着迷又令人困惑。在这次审查中,我们的目标是开发一个包括LED的系统框架，视网膜昼夜节律和屈光发育。本文总结了LED可能破坏视网膜昼夜节律的可能机制。我们建议长时间暴露于LED可能会通过破坏视网膜昼夜节律而诱发近视。最后,我们提出了几种可能的对策，以防止LED干扰视网膜昼夜节律，希望减少近视的发生和发展。
