Abstract：
Epidemiologic studies have revealed that consuming green tea or coffee reduces diabetes risk. We evaluated the effects of the combined consumption of green tea catechins and coffee chlorogenic acids (GTC+CCA) on postprandial glucose, the insulin incretin response, and insulin sensitivity. Eleven healthy men were recruited for this randomized, double-blinded, placebo-controlled crossover trial. The participants consumed a GTC+CCA-enriched beverage (620 mg GTC, 373 mg CCA, and 119 mg caffeine/day) for three weeks; the placebo beverages (PLA) contained no GTC or CCA (PLA: 0 mg GTC, 0 mg CCA, and 119 mg caffeine/day). Postprandial glucose, insulin, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) responses were measured at baseline and after treatments. GTC+CCA consumption for three weeks showed a significant treatment-by-time interaction on glucose changes after the ingestion of high-fat and high-carbohydrate meals, however, it did not affect fasting glucose levels. Insulin sensitivity was enhanced by GCT+CCA compared with PLA. GTC+CCA consumption resulted in a significant increase in postprandial GLP-1 and a decrease in GIP compared to PLA. Consuming a combination of GTC and CCA for three weeks significantly improved postprandial glycemic control, GLP-1 response, and postprandial insulin sensitivity in healthy individuals and may be effective in preventing diabetes.
摘要：
流行病学研究表明，饮用绿茶或咖啡可降低糖尿病风险。我们评估了绿茶儿茶素和咖啡绿原酸（GTCCCA）的联合消费对餐后葡萄糖的影响，胰岛素肠促胰岛素反应，和胰岛素敏感性。这项随机调查招募了11名健康男性，双盲,安慰剂对照交叉试验。参与者饮用了富含GTC+CCA的饮料(620mgGTC，373毫克CCA，和119毫克咖啡因/天），持续三周；安慰剂饮料（PLA）不含GTC或CCA（PLA：0毫克GTC，0mgCCA，和119毫克咖啡因/天）。餐后葡萄糖，胰岛素，胰高血糖素样肽-1(GLP-1),在基线和治疗后测量葡萄糖依赖性促胰岛素多肽（GIP）反应。GTC+CCA摄入三周后，对摄入高脂肪和高碳水化合物膳食后的葡萄糖变化显示出显著的治疗时间相互作用，然而,它不影响空腹血糖水平.与PLA相比，GCT+CCA增强了胰岛素敏感性。与PLA相比,GTC+CCA消耗导致餐后GLP-1的显著增加和GIP的降低。服用GTC和CCA组合3周可显著改善餐后血糖控制，GLP-1反应，健康个体的餐后胰岛素敏感性，可能有效预防糖尿病。
