Abstract：
Secretoneurin (SN) is a 33 amino-acid evolutionary conserved neuropeptide from the chromogranin peptide family. SN\'s main effects may be cardioprotective and are believed to be mediated through its inhibition of calmodulin-dependent kinase II (CaMKII), which influences intracellular calcium handling. SN inhibition of CaMKII suppresses calcium leakage from the sarcoplasmic reticulum through the ryanodine receptor. This action may reduce the risk of ventricular arrhythmias and calcium-dependent remodelling in heart failure. SN is also involved in reducing the intracellular reactive oxygen species concentration, modulating the immune response, and regulating the cell cycle, including apoptosis. SN can predict mortality in different disease states, beyond the classical risk factors and markers of myocardial injury. Plasma SN levels are elevated soon after an arrhythmogenic episode. In summary, SN is a novel biomarker with potential in cardiovascular medicine, and probably beyond.
摘要：
分泌神经素（SN）是嗜铬粒蛋白肽家族的33个氨基酸进化保守的神经肽。SN的主要作用可能是心脏保护作用，并被认为是通过其抑制钙调蛋白依赖性激酶II（CaMKII）介导的，影响细胞内钙的处理。CaMKII的SN抑制抑制钙通过ryanodine受体从肌浆网泄漏。这种作用可以降低心力衰竭中室性心律失常和钙依赖性重塑的风险。SN还参与降低细胞内活性氧的浓度，调节免疫反应，调节细胞周期，包括细胞凋亡。SN可以预测不同疾病状态下的死亡率，超越心肌损伤的经典危险因素和标志物。致心律失常发作后不久血浆SN水平升高。总之,SN是一种在心血管医学中具有潜力的新型生物标志物,而且可能更远。
