PDF(Pubmed)
Abstract：
A layer of proteoglycans and glycoproteins known as glycocalyx covers the surface of the trabecular meshwork (TM), juxtacanalicular tissue (JCT), and Schlemm\'s canal (SC) inner wall of the conventional aqueous outflow pathway in the eye. This has been shown to play a role in the mechanotransduction of fluid shear stress and in the regulation of the outflow resistance. The outflow resistance in the conventional outflow pathway is the main determinant of the intraocular pressure (IOP) through an active, two-way, fluid-structure interaction coupling between the outflow tissues and aqueous humor. A 3D microstructural finite element (FE) model of a healthy human eye TM/JCT/SC complex with interspersed aqueous humor was constructed. A very thin charged double layer that represents the endothelial glycocalyx layer covered the surface of the elastic outflow tissues. The aqueous humor was modeled as electroosmotic flow that is charged when it is in contact with the outflow tissues. The electrical-fluid-structure interaction (EFSI) method was used to couple the charged double layer (glycocalyx), fluid (aqueous humor), and solid (outflow tissues). When the IOP was elevated to 15 mmHg, the maximum aqueous humor velocity in the EFSI model was decreased by 2.35 mm/s (9%) compared to the fluid-structure interaction (FSI) model. The charge or electricity in the living human conventional outflow pathway generated by the charged endothelial glycocalyx layer plays a minor biomechanical role in the resultant stresses and strains as well as the hydrodynamics of the aqueous humor.
摘要：
一层称为糖萼的蛋白聚糖和糖蛋白覆盖小梁网（TM）的表面，耳旁组织（JCT），和Schlemm管（SC）内壁的眼睛中的常规房水流出通道。已证明这在流体剪切应力的机械传导和流出阻力的调节中起作用。常规流出途径中的流出阻力是眼内压（IOP）的主要决定因素，双向,流出组织和房水之间的流体-结构相互作用耦合。建立了散布有房水的健康人眼TM/JCT/SC复合物的3D微结构有限元（FE）模型。代表内皮糖萼层的非常薄的带电双层覆盖了弹性流出组织的表面。房水被建模为电渗流，当其与流出组织接触时带电。电-流体-结构相互作用（EFSI）方法用于耦合带电双层（糖萼），体液（房水），和固体（流出组织）。当眼压升高到15mmHg时,与流体-结构相互作用(FSI)模型相比,EFSI模型中的最大房水速度降低了2.35mm/s(9%).由带电的内皮糖萼层产生的活人常规流出途径中的电荷或电力在所产生的应力和应变以及房水的流体动力学中起着次要的生物力学作用。
