Seventeen older adults with depression and EFD were randomized to iTBS or sham for 6 weeks. Intervention was delivered bilaterally using a recognized connectivity target.
A total of 89% (17/19) participants completed all study procedures. No serious adverse events occurred. Pre to post-intervention change in mean Montgomery-Asberg-depression scores was not different between iTBS or sham, p = 0.33. No significant group-by-time interaction for Montgomery-Asberg Depression rating scale scores (F 3, 44 = 0.51; p = 0.67) was found. No significant differences were seen in the effects of time between the two groups on executive measures: Flanker scores (F 1, 14 = 0.02, p = 0.88), Dimensional-change-card-sort scores F 1, 14 = 0.25, p = 0.63, and working memory scores (F 1, 14 = 0.98, p = 0.34). The Group-by-time interaction effect for functional connectivity (FC) within the Fronto-parietal-network was not significant (F 1, 14 = 0.36, p = 0.56). No significant difference in the effect-of-time between the two groups was found on FC within the Cingulo-opercular-network (F 1, 14 = 0, p = 0.98).
Bilateral iTBS is feasible in LLD. Preliminary results are unsupportive of efficacy on depression, executive function or target engagement of the CCN. A future Randomized clinical trial requires a larger sample size with stratification of cognitive and executive variables and refinement in the target engagement.
方法:17名患有抑郁症和EFD的老年人随机接受iTBS或假手术,为期6周。使用公认的连接目标进行双边干预。
结果:共有89%(17/19)的参与者完成了所有研究程序。无严重不良事件发生。干预前后蒙哥马利-阿斯伯格抑郁平均评分的变化在iTBS或假手术之间没有差异,p=0.33。Montgomery-Asberg抑郁量表评分(F3,44=0.51;p=0.67)没有发现明显的分组时间相互作用。两组的时间对执行措施的影响没有显着差异:Flanker评分(F1,14=0.02,p=0.88),维度变化卡片分类得分F1,14=0.25,p=0.63,工作记忆得分(F1,14=0.98,p=0.34)。Fronto顶叶网络内功能连接(FC)的分组时间相互作用效应不显着(F1,14=0.36,p=0.56)。在Cingulo-opulcular-network中,两组之间的时间效应没有显着差异(F1,14=0,p=0.98)。
结论:双侧iTBS在LLD中是可行的。初步结果不支持抑郁症的疗效,CCN的执行功能或目标参与。未来的随机临床试验需要更大的样本量,对认知和执行变量进行分层,并细化目标参与度。