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Abstract：
BACKGROUND: Asymptomatic infections and mild symptoms are common in patients infected with the Omicron variant, and data on liver test abnormalities are rare.
OBJECTIVE: To evaluated the clinical characteristics of asymptomatic and mild coronavirus disease 2019 (COVID-19) patients with abnormal liver test results.
METHODS: This retrospective study included 661 laboratory-confirmed asymptomatic and mild COVID-19 patients who were treated in two makeshift hospitals in Ningbo from April 5, 2022 to April 29, 2022. Clinical information and viral shedding time were collected, and univariate and multivariate logistic regression models were performed in statistical analyses.
RESULTS: Of the 661 patients, 83 (12.6%) had liver test abnormalities, and 6 (0.9%) had liver injuries. Abnormal liver tests revealed a reliable correlation with a history of liver disease (P < 0.001) and a potential correlation with male sex and obesity (P < 0.05). Elevated alanine aminotransferase was reliably associated with obesity (P < 0.05) and a history of liver disease (P < 0.001). Elevated aspartate transaminase (AST) was reliably correlated with a history of liver disease (P < 0.001), and potentially correlated with age over 30 years (P < 0.05). There was a reliable correlation between AST ≥ 2× the upper limit of normal and a longer viral shedding time, especially in mild cases.
CONCLUSIONS: Obesity and a history of liver disease are risk factors for liver test abnormalities. Being male and an older age are potential risk factors. Attention should be given to liver tests in asymptomatic and mild COVID-19 patients, which has crucial clinical significance for evaluating the viral shedding time.
OBJECTIVE: To evaluated the clinical characteristics of asymptomatic and mild coronavirus disease 2019 (COVID-19) patients with abnormal liver test results.
METHODS: This retrospective study included 661 laboratory-confirmed asymptomatic and mild COVID-19 patients who were treated in two makeshift hospitals in Ningbo from April 5, 2022 to April 29, 2022. Clinical information and viral shedding time were collected, and univariate and multivariate logistic regression models were performed in statistical analyses.
RESULTS: Of the 661 patients, 83 (12.6%) had liver test abnormalities, and 6 (0.9%) had liver injuries. Abnormal liver tests revealed a reliable correlation with a history of liver disease (P < 0.001) and a potential correlation with male sex and obesity (P < 0.05). Elevated alanine aminotransferase was reliably associated with obesity (P < 0.05) and a history of liver disease (P < 0.001). Elevated aspartate transaminase (AST) was reliably correlated with a history of liver disease (P < 0.001), and potentially correlated with age over 30 years (P < 0.05). There was a reliable correlation between AST ≥ 2× the upper limit of normal and a longer viral shedding time, especially in mild cases.
CONCLUSIONS: Obesity and a history of liver disease are risk factors for liver test abnormalities. Being male and an older age are potential risk factors. Attention should be given to liver tests in asymptomatic and mild COVID-19 patients, which has crucial clinical significance for evaluating the viral shedding time.
摘要：
背景：无症状感染和轻度症状在感染Omicron变体的患者中很常见，肝脏检查异常的数据很少见。
目的：评估肝脏检查结果异常的无症状和轻度冠状病毒病2019（COVID-19）患者的临床特征。
方法：这项回顾性研究包括2022年4月5日至2022年4月29日在宁波两家临时医院接受治疗的661例经实验室证实的无症状和轻度COVID-19患者。收集临床信息和病毒脱落时间，在统计分析中使用单变量和多变量逻辑回归模型。
结果：在661名患者中，83（12.6%）有肝脏检查异常，和6（0.9％）肝损伤。异常肝脏检查显示与肝病史可靠相关（P<0.001），与男性和肥胖潜在相关（P<0.05）。丙氨酸转氨酶升高与肥胖（P<0.05）和肝病史（P<0.001）可靠相关。天冬氨酸转氨酶（AST）升高与肝病病史可靠相关（P<0.001），与年龄超过30岁有潜在的相关性(P<0.05)。AST≥2×正常上限与更长的病毒脱落时间之间存在可靠的相关性，特别是在轻微的情况下。
结论：肥胖和肝病史是肝脏检查异常的危险因素。男性和老年人是潜在的危险因素。无症状和轻度COVID-19患者应注意肝脏检查，这对评估病毒脱落时间具有至关重要的临床意义。
目的：评估肝脏检查结果异常的无症状和轻度冠状病毒病2019（COVID-19）患者的临床特征。
方法：这项回顾性研究包括2022年4月5日至2022年4月29日在宁波两家临时医院接受治疗的661例经实验室证实的无症状和轻度COVID-19患者。收集临床信息和病毒脱落时间，在统计分析中使用单变量和多变量逻辑回归模型。
结果：在661名患者中，83（12.6%）有肝脏检查异常，和6（0.9％）肝损伤。异常肝脏检查显示与肝病史可靠相关（P<0.001），与男性和肥胖潜在相关（P<0.05）。丙氨酸转氨酶升高与肥胖（P<0.05）和肝病史（P<0.001）可靠相关。天冬氨酸转氨酶（AST）升高与肝病病史可靠相关（P<0.001），与年龄超过30岁有潜在的相关性(P<0.05)。AST≥2×正常上限与更长的病毒脱落时间之间存在可靠的相关性，特别是在轻微的情况下。
结论：肥胖和肝病史是肝脏检查异常的危险因素。男性和老年人是潜在的危险因素。无症状和轻度COVID-19患者应注意肝脏检查，这对评估病毒脱落时间具有至关重要的临床意义。
