PDF(Pubmed)
Abstract：
Zinc is a trace nutrient essential for the normal growth and development of human body. The main aim was to evaluate the significant association between measured zinc status in relation to different skin disorders and their severity. PubMed®, Google® Scholar™ and Cochrane© Reviews databases were searched for studies from January 2017 to June 2021, using the terms; zinc serum levels, zinc plasma levels and different dermatosis in the review, only human studies in English language were reviewed and the studies designs were controlled, cross sectional, observational and analytic types. A total of forty-eight research studies were included in this review. All studies have evaluated serum zinc in skin diseases including psoriasis, atopic dermatitis, pityriasis alba, androgenetic alopecia areata, telogen effluvium, vitiligo, melasma, acne, seborrheic dermatitis and hidradenitis suppuritiva. It was found that 33 studies had validated statistically significant differences in serum zinc levels between patients and controls. There is a predominance of low serum zinc levels in all the dermatoses reviewed. The clinical significance of this finding highlights the possible value, and need to investigate, the use of Zinc supplementation as an adjuvant therapy in the management of chronic inflammatory and autoimmune skin diseases proven to manifest altered zinc levels.
摘要：
锌是人体正常生长发育所必需的微量营养素。主要目的是评估测得的锌状态与不同皮肤疾病及其严重程度之间的显着关联。PubMed®,Google®Scholar™和Cochrane©Reviews数据库搜索了2017年1月至2021年6月的研究，使用以下术语：锌血清水平，锌血浆水平与不同皮肤病的综述，只有英语的人类研究被审查，研究设计被控制，横截面,观察型和分析型。本综述共纳入48项研究。所有研究都评估了血清锌在皮肤病包括牛皮癣中的作用，特应性皮炎,糠疹,雄激素性斑秃,静止期脱发，白癜风,黄褐斑,痤疮,脂溢性皮炎和化脓性汗腺炎。发现33项研究验证了患者和对照组之间血清锌水平的统计学显着差异。在所审查的所有皮肤病中，血清锌水平低占主导地位。这一发现的临床意义突出了可能的价值，需要调查，在慢性炎症性和自身免疫性皮肤病的治疗中使用锌补充剂作为辅助治疗被证明表现出改变的锌水平。
