A 39-year old Caucasian male with chronic burning mouth pain underwent extensive investigations with no cause of the pain being found. During the course of the investigation, an elevated vitamin B6 (pyridoxal phosphate) level was detected, which led to the diagnosis of hypophosphatasia. We hypothesize that the patient\'s mouth pain stems from hypophosphatasia through a B6 dependent mechanism.
Mouth pain may, in some cases, be a symptom of hypophosphatasia and when investigating B6 in relation to mouth pain, attention should be paid to the exact B6 vitamer measured. The case underlines the importance of low alkaline phosphatase results, especially in patients with unexplained pain, as this should prompt suspicion of hypophosphatasia.
方法:一名39岁的男性白种人患有慢性灼痛的口腔疼痛,接受了广泛的调查,没有发现疼痛的原因。在调查过程中,检测到维生素B6(磷酸吡哆醛)水平升高,导致低磷酸盐血症的诊断。我们假设患者的口腔疼痛通过B6依赖机制源于低磷酸盐血症。
结论:口腔疼痛可能,在某些情况下,是低磷酸盐血症的症状,在调查B6与口腔疼痛的关系时,应注意准确测量B6维生素。该案例强调了低碱性磷酸酶结果的重要性,尤其是有不明原因疼痛的患者,因为这应该引起对低磷酸盐血症的怀疑。