Abstract：
BACKGROUND: Myelomeningocele is a lifelong condition that features several comorbidities, such as hydrocephalus, scoliosis, club foot, and lower limb sensory and motor disabilities. Its management has progressed over time, ranging from supportive care to early postnatal closure to prenatal closure of the defect. Recent research discovered that fetal myelomeningocele closure (fMMC) provided superior neurological outcomes to those of postnatal closure. When performed at 12 months of age, fMMC can avert or delay the need for a ventriculoperitoneal shunt and reversed the hindbrain herniation. Moreover, fMMC reportedly enhanced motor function and mental development at 30 months of age. However, its long-term outcomes remain dubious.
OBJECTIVE: This systematic review aimed to determine the long-term neurological cognitive, behavioral, functional, and quality of life (QoL) outcomes after fMMC.
METHODS: The PubMed, Directory of Open Access Journals, EBSCO, and Cochrane databases were extensively searched for articles published in 2007-2022. Meta-analyses, clinical trials, and randomized controlled trials with at least 5 years of follow-up were given priority.
RESULTS: A total of 11 studies were included. Most studies revealed enhanced long-term cognitive, behavioral, functional, and QoL outcomes after fMMC.
CONCLUSIONS: Our results suggest that fMMC substantially enhanced patients\' long-term neurological cognitive, behavioral, functional, and QoL outcomes.
OBJECTIVE: This systematic review aimed to determine the long-term neurological cognitive, behavioral, functional, and quality of life (QoL) outcomes after fMMC.
METHODS: The PubMed, Directory of Open Access Journals, EBSCO, and Cochrane databases were extensively searched for articles published in 2007-2022. Meta-analyses, clinical trials, and randomized controlled trials with at least 5 years of follow-up were given priority.
RESULTS: A total of 11 studies were included. Most studies revealed enhanced long-term cognitive, behavioral, functional, and QoL outcomes after fMMC.
CONCLUSIONS: Our results suggest that fMMC substantially enhanced patients\' long-term neurological cognitive, behavioral, functional, and QoL outcomes.
摘要：
背景：脑膜膨出是一种终生疾病，具有多种合并症，比如脑积水，脊柱侧弯,球杆脚,下肢感觉和运动障碍。它的管理随着时间的推移而进步，从支持性护理到产后早期关闭到缺陷的产前关闭。最近的研究发现，胎儿脊髓膜膨出封闭（fMMC）提供了优于产后封闭的神经系统结局。当在12个月大的时候进行时，fMMC可以避免或延迟脑室腹膜分流术的需要，并逆转后脑疝。此外，据报道，fMMC在30个月大时增强了运动功能和智力发育。然而,其长期结果仍然可疑。
目的：本系统综述旨在确定长期的神经认知，行为，功能，fMMC后的生活质量（QoL）结果。
方法：PubMed，开放存取期刊目录，EBSCO,和Cochrane数据库广泛搜索2007-2022年发表的文章。荟萃分析，临床试验,并优先考虑至少5年随访的随机对照试验.
结果：共纳入11项研究。大多数研究表明，长期认知能力增强，行为，功能，fMMC后的QoL结果。
结论：我们的结果表明，fMMC大大增强了患者的长期神经认知，行为，功能，和QoL结果。
目的：本系统综述旨在确定长期的神经认知，行为，功能，fMMC后的生活质量（QoL）结果。
方法：PubMed，开放存取期刊目录，EBSCO,和Cochrane数据库广泛搜索2007-2022年发表的文章。荟萃分析，临床试验,并优先考虑至少5年随访的随机对照试验.
结果：共纳入11项研究。大多数研究表明，长期认知能力增强，行为，功能，fMMC后的QoL结果。
结论：我们的结果表明，fMMC大大增强了患者的长期神经认知，行为，功能，和QoL结果。
