PDF(Pubmed)
Abstract：
Long non-coding RNAs are demonstrated to contribute to carcinogenesis. TMPO Antisense RNA 1 (TMPO-AS1) is an example of lncRNAs with crucial roles in this process. This lncRNA serves as a sponge for miR-320a, miR-383-5p, miR-329-3p, miR-126, miR-329, miR-199a-5p, miR-577, miR-4731-5p, miR-140-5p, miR-1179, miR-143-3p, miR-326, miR-383-5p, let-7c-5p, let-7g-5p, miR-199a-5p, miR-200c, miR-204-3p, miR-126-5p, miR-383-5p, miR-498, miR-143-3p, miR-98-5p, miR-140 and miR-143. It can also affect activity of PI3K/Akt/mTOR pathway. The current review summarizes the role of TMPO-AS1 in the carcinogenesis and assessment of its potential as a marker for certain types of cancers.
摘要：
长链非编码RNA被证明有助于致癌作用。TMPO反义RNA1（TMPO-AS1）是在此过程中具有关键作用的lncRNA的一个例子。这个lncRNA充当miR-320a的海绵，miR-383-5p,miR-329-3p,miR-126,miR-329,miR-199a-5p,miR-577,miR-4731-5p,miR-140-5p,miR-1179,miR-143-3p,miR-326,miR-383-5p,let-7c-5p,let-7g-5p,miR-199a-5p,miR-200c,miR-204-3p,miR-126-5p,miR-383-5p,miR-498,miR-143-3p,miR-98-5p,miR-140和miR-143。它还可以影响PI3K/Akt/mTOR通路的活性。本综述总结了TMPO-AS1在癌变中的作用，并评估了其作为某些类型癌症标志物的潜力。
