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Abstract：
UNASSIGNED: To determine whether gross tumor volume (GTV) of adenocarcinoma of esophagogastric junction (AEG) corresponding to cT and cN stages measured on CT could help quantitatively determine resectability.
UNASSIGNED: 343 consecutive patients with AEG, including 279 and 64 randomly enrolled in training cohort (TC) and validation cohort (VC), respectively, underwent preoperative contrast-enhanced CT. Univariate and multivariate analyses for TC were performed to determine factors associated with resectability. Receiver operating characteristic (ROC) analyses were to determine if GTV corresponding to cT and cN stages could help determine resectability. For VC, Cohen\'s Kappa tests were to assess performances of the ROC models.
UNASSIGNED: cT stage, cN stage and GTV were independently associated with resectability of AEG with odds ratios of 4.715, 4.534 and 1.107, respectively. For differentiating resectable and unresectable AEG, ROC analyses showed that cutoff GTV of 32.77 cm3 in stage cT1-4N0-3 with an area under the ROC curve (AUC) of 0.901. Particularly, cutoffs of 27.67 and 32.77 cm3 in stages cT3 and cT4 obtained AUC values of 0.860 and 0.890, respectively; and cutoffs of 27.09, 33.32 and 37.39 cm3 in stages cN1, cN2 and cN3 obtained AUC values of 0.852, 0.821 and 0.902, respectively. In VC, Cohen\'s Kappa tests verified that the ROC models had good performance in distinguishing between resectable and unresectable AEG (all Cohen\'s K values > 0.72).
UNASSIGNED: GTV, cT and cN stages could be independent determinants of resectability of AEG. And GTV corresponding to cT and cN stages can help quantitatively determine resectability.
UNASSIGNED: 343 consecutive patients with AEG, including 279 and 64 randomly enrolled in training cohort (TC) and validation cohort (VC), respectively, underwent preoperative contrast-enhanced CT. Univariate and multivariate analyses for TC were performed to determine factors associated with resectability. Receiver operating characteristic (ROC) analyses were to determine if GTV corresponding to cT and cN stages could help determine resectability. For VC, Cohen\'s Kappa tests were to assess performances of the ROC models.
UNASSIGNED: cT stage, cN stage and GTV were independently associated with resectability of AEG with odds ratios of 4.715, 4.534 and 1.107, respectively. For differentiating resectable and unresectable AEG, ROC analyses showed that cutoff GTV of 32.77 cm3 in stage cT1-4N0-3 with an area under the ROC curve (AUC) of 0.901. Particularly, cutoffs of 27.67 and 32.77 cm3 in stages cT3 and cT4 obtained AUC values of 0.860 and 0.890, respectively; and cutoffs of 27.09, 33.32 and 37.39 cm3 in stages cN1, cN2 and cN3 obtained AUC values of 0.852, 0.821 and 0.902, respectively. In VC, Cohen\'s Kappa tests verified that the ROC models had good performance in distinguishing between resectable and unresectable AEG (all Cohen\'s K values > 0.72).
UNASSIGNED: GTV, cT and cN stages could be independent determinants of resectability of AEG. And GTV corresponding to cT and cN stages can help quantitatively determine resectability.
摘要：
UNASSIGNED：确定与CT测量的cT和cN分期相对应的食管胃结合部腺癌（AEG）的大体肿瘤体积（GTV）是否有助于定量确定可切除性。
未经证实：343名连续AEG患者，包括279和64随机参加训练队列(TC)和验证队列(VC)，分别,术前行CT增强扫描。对TC进行单变量和多变量分析以确定与可切除性相关的因素。接收器工作特性（ROC）分析是为了确定对应于cT和cN级的GTV是否可以帮助确定可切除性。对于VC，Cohen的Kappa测试用于评估ROC模型的性能。
未经批准：cT阶段，cN分期和GTV与AEG可切除性独立相关，比值比分别为4.715、4.534和1.107。为了区分可切除和不可切除的AEG，ROC分析显示cT1-4N0-3阶段的截止GTV为32.77cm3,ROC曲线下面积(AUC)为0.901。特别是,cT3和cT4阶段的截止值分别为27.67和32.77cm3，获得的AUC值分别为0.860和0.890；cN1，cN2和cN3阶段的截止值分别为27.09、33.32和37.39cm3，获得的AUC值分别为0.852、0.821和0.902。在VC中,Cohen的Kappa测试验证了ROC模型在区分可切除和不可切除的AEG方面具有良好的性能（所有Cohen的K值>0.72）。
未经批准：GTV，cT和cN阶段可能是AEG可切除性的独立决定因素。与cT和cN阶段相对应的GTV可以帮助定量确定可切除性。
未经证实：343名连续AEG患者，包括279和64随机参加训练队列(TC)和验证队列(VC)，分别,术前行CT增强扫描。对TC进行单变量和多变量分析以确定与可切除性相关的因素。接收器工作特性（ROC）分析是为了确定对应于cT和cN级的GTV是否可以帮助确定可切除性。对于VC，Cohen的Kappa测试用于评估ROC模型的性能。
未经批准：cT阶段，cN分期和GTV与AEG可切除性独立相关，比值比分别为4.715、4.534和1.107。为了区分可切除和不可切除的AEG，ROC分析显示cT1-4N0-3阶段的截止GTV为32.77cm3,ROC曲线下面积(AUC)为0.901。特别是,cT3和cT4阶段的截止值分别为27.67和32.77cm3，获得的AUC值分别为0.860和0.890；cN1，cN2和cN3阶段的截止值分别为27.09、33.32和37.39cm3，获得的AUC值分别为0.852、0.821和0.902。在VC中,Cohen的Kappa测试验证了ROC模型在区分可切除和不可切除的AEG方面具有良好的性能（所有Cohen的K值>0.72）。
未经批准：GTV，cT和cN阶段可能是AEG可切除性的独立决定因素。与cT和cN阶段相对应的GTV可以帮助定量确定可切除性。
