Abstract：
The main objectives of the current study are to investigate valvular involvement in patients with cardiac Behçet\'s disease (BD) and find out the risk factors of valvular involvement in cardiac BD. We retrospectively assessed the clinical and echocardiographic data in the medical records of 121 patients with BD admitted to Beijing Anzhen Hospital from January 2015 to January 2022. We evaluated the valvular structure and function mainly by echocardiography. A total of 77 BD patients (77/121, 63.64%) had cardiac valvular involvement. Valvular lesions occurred more frequently in males (p = 0.022). Aortic regurgitation (AR) (62/77, 80.52%) was the most common finding and severe AR occupied 80.65% (50/62). The most common manifestations of BD patients with severe AR was aortic valve prolapse (25/50, 50%), followed by echo-free spaces within the aortic annulus (11/50, 22%), vegetation-like lesions (10/50, 20%), and aortic root aneurysm (10/50, 20%). The incidence of paravalvular leaks (PVL) in BD patients was 14.29% (7/49). The diameter of the sinus of Valsalva and proximal ascending aorta, and total cholesterol (TCHO) were the independent risk factors of moderate-severe aortic valvular regurgitation (p < 0.01). Left ventricular end-diastolic dimension (LVEDD), left ventricular ejection fraction (LVEF) and brain natriuretic peptide (BNP) were significantly associated with moderate-severe mitral valvular regurgitation (p < 0.01). The most common valvular abnormality in BD is AR. Echocardiography has great value in the comprehensive evaluation and accurate diagnosis of valvular involvement in BD patients.
摘要：
本研究的主要目的是调查心脏Behçet病（BD）患者的瓣膜受累情况，并找出心脏BD患者瓣膜受累的危险因素。我们回顾性评估了2015年1月至2022年1月北京安贞医院收治的121例BD患者的临床和超声心动图资料。我们主要通过超声心动图评估瓣膜的结构和功能。共有77例BD患者（77/121，63.64％）有心脏瓣膜受累。瓣膜病变在男性中更常见（p=0.022）。主动脉瓣反流（AR）（62/77，80.52％）是最常见的发现，重度AR占80.65％（50/62）。BD合并重度AR患者最常见的表现是主动脉瓣脱垂(25/50,50%),其次是主动脉瓣环内无回声空间（11/50，22%），植被样病变(10/50，20%)，和主动脉根瘤（10/50，20%）。BD患者的瓣周漏(PVL)发生率为14.29%(7/49)。Valsalva窦和升主动脉近端直径,总胆固醇(TCHO)是中重度主动脉瓣关闭不全的独立危险因素(p<0.01)。左心室舒张末期内径(LVEDD),左心室射血分数(LVEF)和脑钠肽(BNP)与中重度二尖瓣反流显著相关(p<0.01)。BD中最常见的瓣膜异常是AR。超声心动图对BD患者瓣膜受累的综合评价和准确诊断具有重要价值。
