UNASSIGNED: This study was a randomized, double-blind clinical trial. The study included 72 children under 12 years of age under mechanical ventilation for more than 48 h in the Mofid Children\'s Hospital. Patients were randomly divided into Limosilactobacillus reuteri DSM 17938 probiotic recipients (n = 38) and placebo groups (n = 34). In addition to the standard treatment, both groups received a sachet containing probiotics or a placebo twice a day. Children were screened for VAP based on clinical and laboratory evidence.
UNASSIGNED: The mean age of children in the intervention and placebo groups was 4.60 ± 4.84 and 3.38 ± 3.49 years, respectively. After adjusting the other variables, it was observed that chance of VAP among probiotics compared to the placebo group was significantly decreased (OR adjusted = 0.29; 95% CI: 0.09-0.95). Also, probiotic was associated with a significantly lower chance of diarrhea than the placebo group (OR adjusted = 0.09; 95% CI: 0.01-0.96).
UNASSIGNED: Probiotic utilization is effective in preventing the incidence of VAP and diarrhea in children under mechanical ventilation in the PICU.
未经评估:这项研究是一项随机研究,双盲临床试验。该研究包括72名12岁以下的儿童在Mofid儿童医院接受机械通气超过48小时。患者被随机分为罗伊氏LimosilactobacillusDSM17938益生菌接受者(n=38)和安慰剂组(n=34)。除了标准治疗,两组均接受含益生菌的小袋或安慰剂,每天两次.根据临床和实验室证据对儿童进行VAP筛查。
未经评估:干预组和安慰剂组儿童的平均年龄分别为4.60±4.84和3.38±3.49岁,分别。调整其他变量后,观察到,与安慰剂组相比,益生菌组发生VAP的几率显著降低(OR校正=0.29;95%CI:0.09~0.95).此外,与安慰剂组相比,益生菌组出现腹泻的几率显著降低(OR校正=0.09;95%CI:0.01~0.96).
UNASSIGNED:益生菌的使用可有效预防PICU机械通气儿童的VAP和腹泻的发生。