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Abstract：
CIPKs are a subclass of serine/threonine (Ser/Thr) protein kinases. CBLs are ubiquitous Ca2+ sensors that interact with CIPK with the aid of secondary Ca2+ messengers for regulation of growth and development and response to stresses faced by plants. The divergent roles of the CIPK-CBL interaction in plants include responding to environmental stresses (salt, cold, drought, pH, ABA signaling, and ion toxicity), ion homeostasis (K+, NH4 +, NO3 -, and microelement homeostasis), biotic stress, and plant development. Each member of this gene family produces distinct proteins that help plants adapt to diverse stresses or stimuli by interacting with calcium ion signals. CIPK consists of two structural domains-an N-terminal domain and a C-terminal domain-connected by a junction domain. The N-terminal domain, the site of phosphorylation, is also called the activation domain and kinase domain. The C-terminal, also known as the regulatory domain of CIPK, further comprises NAF/FISL and PPI. CBL comprises four EF domains and conserved PFPF motifs and is the site of binding with the NAF/FISL domain of CIPK to form a CBL-CIPK complex. In addition, we also performed a bibliometric analysis of the CIPK gene family of data extracted from the WoSCC. A total of 95 documents were retrieved, which had been published by 47 sources. The production over time was zigzagged. The top key terms were gene, CIPK, abiotic stress, and gene expression. Beijing Forestry University was the top affiliation, while The Plant Cell was the top source. The genomics and metabolomics of this gene family require more study.
摘要：
ClPKs是丝氨酸/苏氨酸(Ser/Thr)蛋白激酶的亚类。CBL是普遍存在的Ca2传感器，可在次级Ca2信使的帮助下与CIPK相互作用，以调节植物的生长和发育以及对植物面临的胁迫的响应。CIPK-CBL相互作用在植物中的不同作用包括对环境胁迫(盐，冷,干旱,pH值,ABA信号,和离子毒性)，离子稳态(K+，NH4+,NO3-,和微量元素稳态)，生物应激，和植物发育。该基因家族的每个成员都产生不同的蛋白质，这些蛋白质通过与钙离子信号相互作用来帮助植物适应各种胁迫或刺激。CIPK由两个结构域组成-N末端结构域和C末端结构域-通过接合结构域连接。N端域，磷酸化位点，也称为激活域和激酶域。C端,也被称为CIPK的调节域，还包括NAF/FISL和PPI。CBL包含四个EF结构域和保守的PFPF基序，并且是与CIPK的NAF/FISL结构域结合以形成CBL-CIPK复合物的位点。此外,我们还对从WoSCC中提取的CIPK基因家族数据进行了文献计量学分析.共检索到95份文件,已由47个来源发布。随着时间的推移，生产呈锯齿状。最关键的术语是基因，CIPK,非生物胁迫，和基因表达。北京林业大学是最高隶属关系，而植物细胞是最高来源。该基因家族的基因组学和代谢组学需要更多的研究。
