Abstract：
Institutional surgical antibiotic prophylaxis (SAP) guidelines are in place at all public hospitals in Singapore, but variations exist and adherence to guidelines is not tracked consistently. A national point prevalence survey carried out in 2020 showed that about 60% of surgical prophylactic antibiotics were administered for more than 24 hours. This guideline aims to align best practices nationally and provides a framework for audit and surveillance.
This guideline was developed by the National Antimicrobial Stewardship Expert Panel\'s National Surgical Antibiotic Prophylaxis Guideline Development Workgroup Panel, which comprises infectious diseases physicians, pharmacists, surgeons and anaesthesiologists. The Workgroup adopted the ADAPTE methodology framework with modifications for the development of the guideline. The recommended duration of antibiotic prophylaxis was graded according to the strength of consolidated evidence based on the scoring system of the Singapore Ministry of Health Clinical Practice Guidelines.
This National SAP Guideline provides evidence-based recommendations for the rational use of antibiotic prophylaxis. These include recommended agents, dose, timing and duration for patients undergoing common surgeries based on surgical disciplines. The Workgroup also provides antibiotic recommendations for special patient population groups (such as patients with β-lactam allergy and patients colonised with methicillin-resistant Staphylococcus aureus), as well as for monitoring and surveillance of SAP.
This evidence-based National SAP Guideline for hospitals in Singapore aims to align practices and optimise the use of antibiotics for surgical prophylaxis for the prevention of surgical site infections while reducing adverse events from prolonged durations of SAP.
This guideline was developed by the National Antimicrobial Stewardship Expert Panel\'s National Surgical Antibiotic Prophylaxis Guideline Development Workgroup Panel, which comprises infectious diseases physicians, pharmacists, surgeons and anaesthesiologists. The Workgroup adopted the ADAPTE methodology framework with modifications for the development of the guideline. The recommended duration of antibiotic prophylaxis was graded according to the strength of consolidated evidence based on the scoring system of the Singapore Ministry of Health Clinical Practice Guidelines.
This National SAP Guideline provides evidence-based recommendations for the rational use of antibiotic prophylaxis. These include recommended agents, dose, timing and duration for patients undergoing common surgeries based on surgical disciplines. The Workgroup also provides antibiotic recommendations for special patient population groups (such as patients with β-lactam allergy and patients colonised with methicillin-resistant Staphylococcus aureus), as well as for monitoring and surveillance of SAP.
This evidence-based National SAP Guideline for hospitals in Singapore aims to align practices and optimise the use of antibiotics for surgical prophylaxis for the prevention of surgical site infections while reducing adverse events from prolonged durations of SAP.
摘要：
新加坡所有公立医院都制定了机构外科抗生素预防（SAP）指南，但是存在差异，并且无法一致地跟踪对指南的遵守情况。2020年进行的全国点患病率调查显示，约60％的外科预防性抗生素使用时间超过24小时。该指南旨在调整全国最佳做法，并为审计和监督提供框架。
本指南由国家抗菌药物管理专家小组的国家外科抗生素预防指南开发工作组小组制定，其中包括传染病医生，药剂师,外科医生和麻醉师。工作组采用了ADAPTE方法框架，并对指南的制定进行了修改。根据新加坡卫生部临床实践指南的评分系统，根据综合证据的强度对推荐的抗生素预防持续时间进行分级。
本国家SAP指南为合理使用抗生素预防提供了循证建议。这些包括推荐的代理商，剂量,根据外科学科进行普通手术的时间和持续时间。工作组还为特殊患者群体（如β-内酰胺过敏患者和耐甲氧西林金黄色葡萄球菌定植患者）提供抗生素建议，以及对SAP的监控和监督。
本基于证据的新加坡医院国家SAP指南旨在调整实践并优化手术预防中抗生素的使用，以预防手术部位感染，同时减少因SAP持续时间延长而导致的不良事件。
本指南由国家抗菌药物管理专家小组的国家外科抗生素预防指南开发工作组小组制定，其中包括传染病医生，药剂师,外科医生和麻醉师。工作组采用了ADAPTE方法框架，并对指南的制定进行了修改。根据新加坡卫生部临床实践指南的评分系统，根据综合证据的强度对推荐的抗生素预防持续时间进行分级。
本国家SAP指南为合理使用抗生素预防提供了循证建议。这些包括推荐的代理商，剂量,根据外科学科进行普通手术的时间和持续时间。工作组还为特殊患者群体（如β-内酰胺过敏患者和耐甲氧西林金黄色葡萄球菌定植患者）提供抗生素建议，以及对SAP的监控和监督。
本基于证据的新加坡医院国家SAP指南旨在调整实践并优化手术预防中抗生素的使用，以预防手术部位感染，同时减少因SAP持续时间延长而导致的不良事件。
