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Abstract：
Cofilin, as a depolymerization factor of actin filaments, has been widely studied. Evidences show that cofilin has a role in actin structural reorganization and dynamic regulation. In recent years, several studies have demonstrated a regulatory role for cofilin in the migration and invasion mediated by cell dynamics and epithelial to mesenchymal transition (EMT)/EMT-like process, apoptosis, radiotherapy resistance, immune escape, and transcriptional dysregulation of malignant tumor cells, particularly glioma cells. On this basis, it is practical to evaluate cofilin as a biomarker for predicting tumor metastasis and prognosis. Targeting cofilin regulating kinases, Lin11, Isl-1 and Mec-3 kinases (LIM kinases/LIMKs) and their major upstream molecules inhibits tumor cell migration and invasion and targeting cofilin-mediated mitochondrial pathway induces apoptosis of tumor cells represent effective options for the development of novel anti-malignant tumor drug, especially anti-glioma drugs. This review explores the structure, general biological function, and regulation of cofilin, with an emphasis on the critical functions and prospects for clinical therapeutic applications of cofilin in malignant tumors represented by glioma.
摘要：
Cofilin,作为肌动蛋白丝的解聚因子，已被广泛研究。证据表明，cofilin在肌动蛋白结构重组和动态调节中起作用。近年来,多项研究表明，cofilin在细胞动力学和上皮向间充质转化（EMT）/EMT样过程介导的迁移和侵袭中具有调节作用，凋亡，放疗抵抗,免疫逃逸，和恶性肿瘤细胞的转录失调，尤其是神经胶质瘤细胞.在此基础上,将cofilin作为预测肿瘤转移和预后的生物标志物进行评估是可行的。靶向cofilin调节激酶，Lin11，Isl-1和Mec-3激酶（LIM激酶/LIMKs）及其主要上游分子抑制肿瘤细胞迁移和侵袭，靶向cofilin介导的线粒体途径诱导肿瘤细胞凋亡是开发新型抗恶性肿瘤药物的有效选择。尤其是抗神经胶质瘤药物.这篇评论探讨了结构，一般生物学功能，和调节cofilin，重点介绍了cofilin在以神经胶质瘤为代表的恶性肿瘤中的关键功能和临床治疗应用前景。
