PDF(Pubmed)
Abstract：
UNASSIGNED: Due to the increasing prevalence of Kawasaki Disease (KD) in adulthood, the number of women considering pregnancy is growing. There are limited data on the course of pregnancy in KD with coronary artery involvement.
UNASSIGNED: We report on the pregnancy outcome of a 30-year-old woman with KD who was successfully resuscitated for ventricular tachycardia 3 years before. At that time, bypass surgery and later implantable cardioverter-defibrillator implantation were performed because of thrombotically occluded calcified giant coronary aneurysms. The pregnancy course was initially uncomplicated, however, at 31 weeks of gestation, left-sided breast cancer was diagnosed. Weighing maximum therapeutic efficacy against acceptable foetal and maternal cardiotoxic risk, our multidisciplinary team decided on neoadjuvant chemotherapy. The mother and foetus tolerated the therapy well. However, at 36 weeks of gestation, due to HELLP (haemolysis, elevated liver, low platelets) syndrome, a caesarean section had to be performed. The newborn was healthy with good APGAR (appearance, pulse, grimace, activity, respiration) scores. Three weeks after delivery, chemotherapy was restarted and at Week 4 after the caesarean section, the tumour was no more detectable.
UNASSIGNED: We discuss data on pregnancy and KD and outline that pregnancy can be considered if the clinical condition is good and left ventricular function is preserved. We also address possible therapeutic approaches and care for breast cancer in pregnancy and coexisting cardiovascular disease. The extraordinary importance of interdisciplinary cooperation between different disciplines in such complex clinical disease conditions is emphasized.
UNASSIGNED: We report on the pregnancy outcome of a 30-year-old woman with KD who was successfully resuscitated for ventricular tachycardia 3 years before. At that time, bypass surgery and later implantable cardioverter-defibrillator implantation were performed because of thrombotically occluded calcified giant coronary aneurysms. The pregnancy course was initially uncomplicated, however, at 31 weeks of gestation, left-sided breast cancer was diagnosed. Weighing maximum therapeutic efficacy against acceptable foetal and maternal cardiotoxic risk, our multidisciplinary team decided on neoadjuvant chemotherapy. The mother and foetus tolerated the therapy well. However, at 36 weeks of gestation, due to HELLP (haemolysis, elevated liver, low platelets) syndrome, a caesarean section had to be performed. The newborn was healthy with good APGAR (appearance, pulse, grimace, activity, respiration) scores. Three weeks after delivery, chemotherapy was restarted and at Week 4 after the caesarean section, the tumour was no more detectable.
UNASSIGNED: We discuss data on pregnancy and KD and outline that pregnancy can be considered if the clinical condition is good and left ventricular function is preserved. We also address possible therapeutic approaches and care for breast cancer in pregnancy and coexisting cardiovascular disease. The extraordinary importance of interdisciplinary cooperation between different disciplines in such complex clinical disease conditions is emphasized.
摘要：
未经证实：由于成年后川崎病（KD）的患病率不断增加，考虑怀孕的妇女人数正在增加。关于KD合并冠状动脉受累的妊娠过程的数据有限。
UNASSIGNED：我们报告了一名30岁的KD女性的妊娠结局，该女性在3年前成功复苏室性心动过速。当时,由于血栓阻塞的钙化巨大冠状动脉瘤,我们进行了旁路手术和后来的植入式心律转复除颤器植入.怀孕过程最初并不复杂，然而,妊娠31周时，诊断为左侧乳腺癌。权衡最大治疗功效与可接受的胎儿和母体心脏毒性风险，我们的多学科团队决定采用新辅助化疗.母亲和胎儿对治疗的耐受性很好。然而,在妊娠36周时，由于HELLP（溶血，肝脏升高，低血小板）综合征，必须进行剖腹产。新生儿健康，APGAR良好(外观，脉搏,鬼脸,活动,呼吸)评分。分娩后三周，化疗重新开始，在剖腹产后第4周，肿瘤不再被检测到。
UNASSIGNED：我们讨论了有关妊娠和KD的数据，并概述了如果临床状况良好且左心室功能得到保留，则可以考虑妊娠。我们还探讨了妊娠乳腺癌和并存心血管疾病的可能治疗方法和护理。强调了在这种复杂的临床疾病条件下，不同学科之间的跨学科合作的重要性。
UNASSIGNED：我们报告了一名30岁的KD女性的妊娠结局，该女性在3年前成功复苏室性心动过速。当时,由于血栓阻塞的钙化巨大冠状动脉瘤,我们进行了旁路手术和后来的植入式心律转复除颤器植入.怀孕过程最初并不复杂，然而,妊娠31周时，诊断为左侧乳腺癌。权衡最大治疗功效与可接受的胎儿和母体心脏毒性风险，我们的多学科团队决定采用新辅助化疗.母亲和胎儿对治疗的耐受性很好。然而,在妊娠36周时，由于HELLP（溶血，肝脏升高，低血小板）综合征，必须进行剖腹产。新生儿健康，APGAR良好(外观，脉搏,鬼脸,活动,呼吸)评分。分娩后三周，化疗重新开始，在剖腹产后第4周，肿瘤不再被检测到。
UNASSIGNED：我们讨论了有关妊娠和KD的数据，并概述了如果临床状况良好且左心室功能得到保留，则可以考虑妊娠。我们还探讨了妊娠乳腺癌和并存心血管疾病的可能治疗方法和护理。强调了在这种复杂的临床疾病条件下，不同学科之间的跨学科合作的重要性。
