Abstract：
BACKGROUND: 5-Fluorouracil (5-FU) and actinomycin D (ActD) are often used in chemotherapy for various cancers. Side effects are more common in bone marrow suppression, liver function impairment, and gastrointestinal responses. Skin effects are rare and easy to be ignored by doctors and patients, which can lead to life-threatening consequence.
METHODS: We reported a 45-year-old woman patient developed skin erythema and fingernail belt in chemotherapy of 5-FU and ActD.
METHODS: Erythema multiforme drug eruption.
METHODS: Laboratory tests including blood and urine routine, liver and kidney function, electrolytes and coagulation function and close observation.
RESULTS: The rash was gone and the nail change returned.
CONCLUSIONS: Delays in diagnosis or treatment may lead to serious consequence. We should pay attention to the dosage of 5-FU and ActD, monitor adverse reactions strictly, to reduce occurrence of skin malignant events.
METHODS: We reported a 45-year-old woman patient developed skin erythema and fingernail belt in chemotherapy of 5-FU and ActD.
METHODS: Erythema multiforme drug eruption.
METHODS: Laboratory tests including blood and urine routine, liver and kidney function, electrolytes and coagulation function and close observation.
RESULTS: The rash was gone and the nail change returned.
CONCLUSIONS: Delays in diagnosis or treatment may lead to serious consequence. We should pay attention to the dosage of 5-FU and ActD, monitor adverse reactions strictly, to reduce occurrence of skin malignant events.
摘要：
背景：5-氟尿嘧啶（5-FU）和放线菌素D（ActD）通常用于各种癌症的化学疗法。副作用在骨髓抑制中更常见，肝功能损害，和胃肠道反应。皮肤效应很少见,容易被医生和患者忽视,会导致危及生命的后果.
方法：我们报道了一名45岁女性患者在5-FU和ActD化疗中出现皮肤红斑和指甲带。
方法：多形性红斑药疹。
方法：实验室检查包括血液和尿常规，肝肾功能,电解质和凝血功能并密切观察。
结果：皮疹消失，指甲变化恢复。
结论：延误诊断或治疗可能导致严重后果。我们应该注意5-FU和ActD的剂量，严格监测不良反应,减少皮肤恶性肿瘤的发生。
方法：我们报道了一名45岁女性患者在5-FU和ActD化疗中出现皮肤红斑和指甲带。
方法：多形性红斑药疹。
方法：实验室检查包括血液和尿常规，肝肾功能,电解质和凝血功能并密切观察。
结果：皮疹消失，指甲变化恢复。
结论：延误诊断或治疗可能导致严重后果。我们应该注意5-FU和ActD的剂量，严格监测不良反应,减少皮肤恶性肿瘤的发生。
