PDF(Pubmed)
Abstract：
This study aimed to explore the vitamin D status of children in northern China and the association between vitamin D and glucose metabolism.
Cross-sectional study was conducted among child participants and retrospective study designs were conducted among adult participants.
Both studies were recruited from Harbin, 326 children were included in children\'s study, 8469 adults were included in adult study.
Physical examination, lifestyle and dietary habit data were recorded in all the participants. Serum insulin, glucose, 25(OH)D3 concentrations in children and serum glucose and lipids levels in adults were measured. Rickets history was also investigated in adults, which was used to define vitamin D deficiency in childhood. The associations were tested by linear regression and binary logistic regression.
In the children\'s study, only 10.7% of participants were vitamin D sufficient (≥30 ng/mL). Inverse correlations between serum 25(OH)D3 concentration and fasting insulin and homeostasis model assessment - insulin resistance (HOMA-IR) were found, and children with lower serum 25(OH)D3 concentrations were likely to have insulin resistance (IR) (OR: 0.955, 95% CI: 0.917 to 0.995, p value: 0.027). In an adult study, rickets in childhood increased the risk of type 2 diabetes in male participants (OR=1.414, 95% CI=1.013 to 1.972; p value=0.042), but this result was not observed in female participants.
Our findings suggest that vitamin D deficiency is widespread in northern China. Vitamin D deficiency in childhood was associated with IR and increased the risk of type 2 diabetes in male adults.
Cross-sectional study was conducted among child participants and retrospective study designs were conducted among adult participants.
Both studies were recruited from Harbin, 326 children were included in children\'s study, 8469 adults were included in adult study.
Physical examination, lifestyle and dietary habit data were recorded in all the participants. Serum insulin, glucose, 25(OH)D3 concentrations in children and serum glucose and lipids levels in adults were measured. Rickets history was also investigated in adults, which was used to define vitamin D deficiency in childhood. The associations were tested by linear regression and binary logistic regression.
In the children\'s study, only 10.7% of participants were vitamin D sufficient (≥30 ng/mL). Inverse correlations between serum 25(OH)D3 concentration and fasting insulin and homeostasis model assessment - insulin resistance (HOMA-IR) were found, and children with lower serum 25(OH)D3 concentrations were likely to have insulin resistance (IR) (OR: 0.955, 95% CI: 0.917 to 0.995, p value: 0.027). In an adult study, rickets in childhood increased the risk of type 2 diabetes in male participants (OR=1.414, 95% CI=1.013 to 1.972; p value=0.042), but this result was not observed in female participants.
Our findings suggest that vitamin D deficiency is widespread in northern China. Vitamin D deficiency in childhood was associated with IR and increased the risk of type 2 diabetes in male adults.
摘要：
本研究旨在探讨中国北方儿童维生素D水平及其与糖代谢的关系。
在儿童参与者中进行横断面研究，在成人参与者中进行回顾性研究设计。
两项研究均来自哈尔滨，326名儿童被纳入儿童研究，8469名成年人被纳入成人研究。
体格检查,记录所有参与者的生活方式和饮食习惯数据.血清胰岛素，葡萄糖，测量儿童的25（OH）D3浓度以及成人的血清葡萄糖和脂质水平。还调查了成年人的病史，用于定义儿童维生素D缺乏。通过线性回归和二元逻辑回归检验相关性。
在儿童的研究中，只有10.7%的参与者维生素D充足(≥30ng/mL).发现血清25（OH）D3浓度与空腹胰岛素和稳态模型评估-胰岛素抵抗（HOMA-IR）之间存在负相关，血清25(OH)D3浓度较低的儿童可能存在胰岛素抵抗(IR)(OR:0.955,95%CI:0.917~0.995,p值:0.027).在一项成人研究中，儿童期的病增加了男性参与者患2型糖尿病的风险(OR=1.414,95%CI=1.013~1.972;p值=0.042),但这一结果在女性参与者中没有观察到。
我们的研究结果表明，维生素D缺乏在中国北方普遍存在。儿童期维生素D缺乏与IR相关，并增加男性成人2型糖尿病的风险。
在儿童参与者中进行横断面研究，在成人参与者中进行回顾性研究设计。
两项研究均来自哈尔滨，326名儿童被纳入儿童研究，8469名成年人被纳入成人研究。
体格检查,记录所有参与者的生活方式和饮食习惯数据.血清胰岛素，葡萄糖，测量儿童的25（OH）D3浓度以及成人的血清葡萄糖和脂质水平。还调查了成年人的病史，用于定义儿童维生素D缺乏。通过线性回归和二元逻辑回归检验相关性。
在儿童的研究中，只有10.7%的参与者维生素D充足(≥30ng/mL).发现血清25（OH）D3浓度与空腹胰岛素和稳态模型评估-胰岛素抵抗（HOMA-IR）之间存在负相关，血清25(OH)D3浓度较低的儿童可能存在胰岛素抵抗(IR)(OR:0.955,95%CI:0.917~0.995,p值:0.027).在一项成人研究中，儿童期的病增加了男性参与者患2型糖尿病的风险(OR=1.414,95%CI=1.013~1.972;p值=0.042),但这一结果在女性参与者中没有观察到。
我们的研究结果表明，维生素D缺乏在中国北方普遍存在。儿童期维生素D缺乏与IR相关，并增加男性成人2型糖尿病的风险。
