Abstract：
BACKGROUND: Recently, an increasing number of studies have been conducted on circular RNAs (circRNAs) that have demonstrated their different roles in a variety of biological processes. Moreover, a large number of circRNAs have been shown to be involved in the occurrence and development of breast cancer (BC).
METHODS: Both functional and mechanistic experiments have shown that circular RNAs (circRNAs) can act as competing endogenous RNAs by sponging miRNAs, encoding proteins, and regulating parental genes. In doing so, circRNAs modulate the proliferation, migration, apoptosis, and invasion of BC cells in vitro as well as tumor growth and metastasis in vivo. Moreover, scores of circRNAs have been demonstrated to be related to clinicopathological features, prognosis, and treatment sensitivity in patients with BC; many circRNAs have shown potential as biomarkers for diagnosis, drug sensitivity, and prognosis prediction. Furthermore, researchers have focused on circRNAs as potential therapeutic targets.
CONCLUSIONS: In this review, we briefly summarize the functions and categories of circRNAs, their different roles in BC, and recent research and therapeutic progress related to circRNAs.
METHODS: Both functional and mechanistic experiments have shown that circular RNAs (circRNAs) can act as competing endogenous RNAs by sponging miRNAs, encoding proteins, and regulating parental genes. In doing so, circRNAs modulate the proliferation, migration, apoptosis, and invasion of BC cells in vitro as well as tumor growth and metastasis in vivo. Moreover, scores of circRNAs have been demonstrated to be related to clinicopathological features, prognosis, and treatment sensitivity in patients with BC; many circRNAs have shown potential as biomarkers for diagnosis, drug sensitivity, and prognosis prediction. Furthermore, researchers have focused on circRNAs as potential therapeutic targets.
CONCLUSIONS: In this review, we briefly summarize the functions and categories of circRNAs, their different roles in BC, and recent research and therapeutic progress related to circRNAs.
摘要：
背景：最近，越来越多的研究已经对环状RNA(circularRNAs,circRNAs)进行,这些环状RNA已经证明了它们在各种生物过程中的不同作用。此外，大量circRNAs已被证明与乳腺癌的发生和发展有关。
方法：功能和机制实验均表明环状RNA（circularRNAs，circRNAs）可以通过形成miRNAs作为竞争内源性RNAs，编码蛋白质，和调节亲本基因。在这样做的时候，circRNAs调节增殖，迁移,凋亡，和BC细胞的体外侵袭以及体内肿瘤的生长和转移。此外，已证明circRNAs的分数与临床病理特征有关，预后,和BC患者的治疗敏感性；许多circRNAs已显示出作为诊断生物标志物的潜力，药物敏感性,和预后预测。此外，研究人员将circRNAs作为潜在的治疗靶点。
结论：在这篇综述中，我们简要总结了circRNAs的功能和类别，他们在BC中的不同角色，以及与circRNAs相关的最新研究和治疗进展。
方法：功能和机制实验均表明环状RNA（circularRNAs，circRNAs）可以通过形成miRNAs作为竞争内源性RNAs，编码蛋白质，和调节亲本基因。在这样做的时候，circRNAs调节增殖，迁移,凋亡，和BC细胞的体外侵袭以及体内肿瘤的生长和转移。此外，已证明circRNAs的分数与临床病理特征有关，预后,和BC患者的治疗敏感性；许多circRNAs已显示出作为诊断生物标志物的潜力，药物敏感性,和预后预测。此外，研究人员将circRNAs作为潜在的治疗靶点。
结论：在这篇综述中，我们简要总结了circRNAs的功能和类别，他们在BC中的不同角色，以及与circRNAs相关的最新研究和治疗进展。
