Abstract：
OBJECTIVE: The purpose of this study was to assess the role of combined surgical treatment of therapeutic penetrating keratoplasty and pars plana vitrectomy in the anatomical and functional outcome of infectious keratitis endophthalmitis.
METHODS: This study reviewed the medical records of 4 participating centers in the United States and Mexico. This study included patients with a clinical diagnosis of infectious keratitis endophthalmitis who had been treated with an early therapeutic penetrating keratoplasty and pars plana vitrectomy as the main treatment for endophthalmitis. From each medical record, the study retrieved demographic data, relevant medical and drug history, baseline clinical manifestation of endophthalmitis, best-corrected visual acuity, and the need for enucleation/evisceration for the control of the infection or any other reason through the follow-up.
RESULTS: The study included 48 patients (50.15 ± 20.6 years). The mean follow-up time was 13 ± 0.5 months. The mean best-corrected visual acuity at baseline was 2.1 ± 0.25 logarithm of the minimum angle of resolution. At month 12 was 2.09 ± 0.61 logarithm of the minimum angle of resolution ( P = 0.9). The overall prevalence of enucleation/evisceration was 8.3% (95% confidence interval: 2.32%-19.98%). The prevalence of a vision of no-light perception was 20.8% (95% confidence interval: 2.32%-19.98%).
CONCLUSIONS: Combined surgery for severe cases of infectious keratitis endophthalmitis eradicates the infection in most cases, while significantly improving the overall outcomes.
METHODS: This study reviewed the medical records of 4 participating centers in the United States and Mexico. This study included patients with a clinical diagnosis of infectious keratitis endophthalmitis who had been treated with an early therapeutic penetrating keratoplasty and pars plana vitrectomy as the main treatment for endophthalmitis. From each medical record, the study retrieved demographic data, relevant medical and drug history, baseline clinical manifestation of endophthalmitis, best-corrected visual acuity, and the need for enucleation/evisceration for the control of the infection or any other reason through the follow-up.
RESULTS: The study included 48 patients (50.15 ± 20.6 years). The mean follow-up time was 13 ± 0.5 months. The mean best-corrected visual acuity at baseline was 2.1 ± 0.25 logarithm of the minimum angle of resolution. At month 12 was 2.09 ± 0.61 logarithm of the minimum angle of resolution ( P = 0.9). The overall prevalence of enucleation/evisceration was 8.3% (95% confidence interval: 2.32%-19.98%). The prevalence of a vision of no-light perception was 20.8% (95% confidence interval: 2.32%-19.98%).
CONCLUSIONS: Combined surgery for severe cases of infectious keratitis endophthalmitis eradicates the infection in most cases, while significantly improving the overall outcomes.
摘要：
目的：本研究的目的是评估治疗性穿透性角膜移植术和平坦部玻璃体切除术的联合手术治疗在感染性角膜炎眼内炎的解剖和功能结局中的作用。
方法：本研究回顾了美国和墨西哥4个参与中心的医疗记录。这项研究包括临床诊断为感染性角膜炎眼内炎的患者，这些患者已接受早期治疗性穿透性角膜移植术和平坦部玻璃体切除术作为眼内炎的主要治疗方法。从每个医疗记录来看,这项研究检索了人口统计数据，相关病史和药物史，眼内炎的基线临床表现，最佳矫正视力，以及通过随访控制感染或任何其他原因需要摘除/摘除内脏。
结果：该研究包括48名患者（50.15±20.6年）。平均随访时间为13±0.5个月。基线时的平均最佳矫正视力为最小分辨率角度的2.1±0.25对数。在第12个月，最小分辨率角的对数为2.09±0.61（P=0.9）。摘除/摘除内脏的总患病率为8.3%(95%置信区间:2.32%-19.98%)。无光感知视力的患病率为20.8％（95％置信区间：2.32％-19.98％）。
结论：合并手术治疗严重的感染性角膜炎眼内炎可以根除大多数病例的感染，同时显著改善总体结果。
方法：本研究回顾了美国和墨西哥4个参与中心的医疗记录。这项研究包括临床诊断为感染性角膜炎眼内炎的患者，这些患者已接受早期治疗性穿透性角膜移植术和平坦部玻璃体切除术作为眼内炎的主要治疗方法。从每个医疗记录来看,这项研究检索了人口统计数据，相关病史和药物史，眼内炎的基线临床表现，最佳矫正视力，以及通过随访控制感染或任何其他原因需要摘除/摘除内脏。
结果：该研究包括48名患者（50.15±20.6年）。平均随访时间为13±0.5个月。基线时的平均最佳矫正视力为最小分辨率角度的2.1±0.25对数。在第12个月，最小分辨率角的对数为2.09±0.61（P=0.9）。摘除/摘除内脏的总患病率为8.3%(95%置信区间:2.32%-19.98%)。无光感知视力的患病率为20.8％（95％置信区间：2.32％-19.98％）。
结论：合并手术治疗严重的感染性角膜炎眼内炎可以根除大多数病例的感染，同时显著改善总体结果。
