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Abstract：
Introduction Gastric cancer is the fourth most common type of cancer and the second leading cause of cancer-related death in the world. The etiology of gastric cancer includes Helicobacter pylori infection, diet, lifestyle, tobacco, alcohol, and genetic susceptibility. Upper gastrointestinal endoscopy (UGIE) is the most effective method for examining the upper gastrointestinal tract as compared to the other examination tools. Objective To study the histopathological finding of upper gastrointestinal endoscopic biopsies and its association with H. pylori in cases of carcinoma stomach. Materials and methods This was a hospital-based observational study carried out in the Department of Surgery, at Maharaja Krushna Chandra Gajapati Medical College, Berhampur, a tertiary care hospital in Eastern India. Study population consisted of 106 patients for a period of 2 years from July 2019 to June 2021, after due consideration of the inclusion and exclusion criteria. Endoscopic location and pathological types of the gastric lesion were noted, and all biopsy specimens were investigated to see the presence of H. pylori by rapid urease test (RUT) and histological examination in the form of Giemsa and H&E stain. Results In the present study of 106 cases, 62 cases (58.49%) were found to be positive for H. Pylori by RUT and 72 cases (67.92%) were positive for H. pylori by smear staining. In histopathological study, 72 cases (67.92%) were of intestinal type of carcinoma and 34 cases (32.07%) were of diffuse type of carcinoma. Smear for H . pylori was positive in 56 cases (77.78%) among the 72 cases of intestinal type of carcinoma stomach. Whereas only 16 cases (47.05%) were found to be smear-positive for H. pylori among the 34 cases of diffuse type of lesion. Irrespective of histological type, H. pylori was positive in 67.92% of patients with carcinoma stomach. This association was statistically significant (p<0.001) and indicates its role in intestinal type of gastric carcinoma. Conclusion There is a high frequency of H. pylori infection in cases of stomach cancer. This study confirmed the higher association of H. pylori infection with gastric cancer. Its association with the intestinal histological variety of stomach cancer is more common than diffuse type. The prevalence of H. pylori infection in distal stomach carcinoma is higher than proximal.
摘要：
背景技术胃癌是世界上第四大常见类型的癌症,并且是癌症相关死亡的第二大原因。胃癌的病因包括幽门螺杆菌感染,饮食，生活方式,烟草,酒精,和遗传易感性。与其他检查工具相比，上消化道内窥镜检查（UGIE）是检查上消化道的最有效方法。目的探讨胃癌上消化道内镜活检的组织病理学表现及其与幽门螺杆菌的关系。材料和方法这是一项在外科进行的基于医院的观察性研究，在MaharajaKrushnaChandraGajapati医学院，Berhampur,印度东部的一家三级医院。在适当考虑纳入和排除标准后，研究人群由106名患者组成，为期2年，从2019年7月至2021年6月。记录胃镜下病变部位及病理类型,通过快速尿素酶试验（RUT）和Giemsa和H＆E染色的组织学检查，对所有活检标本进行了研究，以观察幽门螺杆菌的存在。结果本研究106例,RUT发现幽门螺杆菌阳性62例（58.49％），涂片染色发现幽门螺杆菌阳性72例（67.92％）。在组织病理学研究中，肠型癌72例（67.92%），弥漫型癌34例（32.07%）。涂抹H.72例肠型胃癌中56例(77.78%)幽门螺杆菌阳性。而在34例弥漫性病变中，只有16例(47.05%)幽门螺杆菌涂片阳性。无论组织学类型，67.92%的胃癌患者幽门螺杆菌阳性。这种相关性具有统计学意义（p<0.001），表明其在肠型胃癌中的作用。结论胃癌患者中H.pylori感染的发生率较高。这项研究证实了幽门螺杆菌感染与胃癌的相关性更高。它与胃癌的肠道组织学变化的关联比弥漫型更常见。远端胃癌的幽门螺杆菌感染率高于近端胃癌。
