PDF(Pubmed)
Abstract：
Keratinophilic fungi are mostly soil-inhabiting organisms with occasional infections in humans and animals. Even though most dermatophytes are host-adapted, cross-species infections are common by zoophilic and geophilic dermatophytes. N. nana is considered an etiological agent of ringworm in pigs but has also been isolated from other animals, including humans. However, it also possesses many characteristics of geophilic dermatophytes including the ability to grow in soil. N. nana produces characteristic pear-shaped macroconidia and usually exhibits an ectothrix pattern of hair infection. It has been isolated from dermatitis lesions as well as from soil. N. nana infections in pigs are not of much concern as far as economy or health is concerned. But it has been associated with onychomycosis and gonathritis in humans, which are significant in human medicine. The shift in the predominance of dermatophytes in humans and the ability to evolve into a potential tinea pathogen necessitates more understanding of the physiology and genetics of N. nana. In this review, we have attempted a detailed analysis of the studies about N. nana, emphasizing growth and cultural characters, physiology, isolation, infection in humans and animals, molecular characterization and antifungal susceptibility.
摘要：
嗜角质真菌主要是居住在土壤中的生物，在人类和动物中偶尔会感染。尽管大多数皮肤癣菌是宿主适应的，跨物种感染是常见的嗜虫和嗜水皮肤癣菌。纳娜被认为是猪癣的病原体，但也从其他动物中分离出来，包括人类。然而,它还具有许多特性的嗜地皮肤癣菌，包括在土壤中生长的能力。N.nana产生特征性的梨形大分生孢子，通常表现出外生体的毛发感染模式。它已从皮炎病变和土壤中分离出来。就经济或健康而言，猪中的N.Nana感染并没有太大问题。但它与人类甲癣和淋病有关，这在人类医学中意义重大。皮肤癣菌在人类中的优势转移以及进化为潜在的癣病原体的能力，需要对N.nana的生理学和遗传学有更多的了解。在这次审查中,我们已经尝试了对NNA的研究的详细分析，强调生长和文化特征，生理学,隔离,人类和动物的感染，分子特征和抗真菌药敏。
