Abstract：
BACKGROUND: Osteoporosis is caused by the deterioration of bone density and microstructure, resulting in increased fracture risk. It transpires due to an imbalanced skeletal remodelling process favouring bone resorption. Various natural compounds can positively influence the skeletal remodelling process, of which naringenin is a candidate. Naringenin is an anti-inflammatory and antioxidant compound found in citrus fruits and grapefruit. This systematic review aims to present an overview of the available evidence on the skeletal protective effects of naringenin.
METHODS: A systematic literature search was conducted using the PubMed and Scopus databases in August 2022. Original research articles using cells, animals, or humans to investigate the bone protective effects of naringenin were included.
RESULTS: Sixteen eligible articles were included in this review. The existing evidence suggested that naringenin enhanced osteoblastogenesis and bone formation through BMP-2/p38MAPK/Runx2/Osx, SDF-1/CXCR4, and PI3K/Akt/c-Fos/c-Jun/AP-1 signalling pathways. Naringenin also inhibited osteoclastogenesis and bone resorption by inhibiting inflammation and the RANKL pathway.
CONCLUSIONS: Naringenin enhances bone formation while suppressing bone resorption, thus achieving its skeletal protective effects. It could be incorporated into the diet through fruit intake or supplements to prevent bone loss.
METHODS: A systematic literature search was conducted using the PubMed and Scopus databases in August 2022. Original research articles using cells, animals, or humans to investigate the bone protective effects of naringenin were included.
RESULTS: Sixteen eligible articles were included in this review. The existing evidence suggested that naringenin enhanced osteoblastogenesis and bone formation through BMP-2/p38MAPK/Runx2/Osx, SDF-1/CXCR4, and PI3K/Akt/c-Fos/c-Jun/AP-1 signalling pathways. Naringenin also inhibited osteoclastogenesis and bone resorption by inhibiting inflammation and the RANKL pathway.
CONCLUSIONS: Naringenin enhances bone formation while suppressing bone resorption, thus achieving its skeletal protective effects. It could be incorporated into the diet through fruit intake or supplements to prevent bone loss.
摘要：
背景：骨质疏松症是由骨密度和微观结构的恶化引起的，导致骨折风险增加。它是由于不平衡的骨骼重塑过程而产生的，这有利于骨吸收。各种天然化合物可以积极影响骨骼重塑过程，Naringenin是其中的候选人。柚皮素是在柑橘类水果和葡萄柚中发现的抗炎和抗氧化化合物。本系统综述旨在概述柚皮素的骨骼保护作用的现有证据。
方法：于2022年8月使用PubMed和Scopus数据库进行了系统的文献检索。使用细胞的原始研究文章，动物,或人类研究柚皮素的骨保护作用被包括在内。
结果：本综述纳入了16篇符合条件的文章。现有证据表明柚皮素通过BMP-2/p38MAPK/Runx2/Osx促进成骨细胞和骨形成，SDF-1/CXCR4和PI3K/Akt/c-Fos/c-Jun/AP-1信号通路。柚皮素还通过抑制炎症和RANKL途径抑制破骨细胞生成和骨吸收。
结论：柚皮素促进骨形成，同时抑制骨吸收，从而实现其骨骼保护作用。它可以通过水果摄入或补充剂纳入饮食中以防止骨质流失。
方法：于2022年8月使用PubMed和Scopus数据库进行了系统的文献检索。使用细胞的原始研究文章，动物,或人类研究柚皮素的骨保护作用被包括在内。
结果：本综述纳入了16篇符合条件的文章。现有证据表明柚皮素通过BMP-2/p38MAPK/Runx2/Osx促进成骨细胞和骨形成，SDF-1/CXCR4和PI3K/Akt/c-Fos/c-Jun/AP-1信号通路。柚皮素还通过抑制炎症和RANKL途径抑制破骨细胞生成和骨吸收。
结论：柚皮素促进骨形成，同时抑制骨吸收，从而实现其骨骼保护作用。它可以通过水果摄入或补充剂纳入饮食中以防止骨质流失。
