PDF(Pubmed)
Abstract：
Dengue infection is common in 129 countries including Pakistan, with an estimated 390 million dengue virus infections per year. Asia accounts for 70% of the actual burden. Clinical signs and symptoms of dengue include a high fever (40°C/104 °F) accompanied by two of the following symptoms during the febrile phase: severe headache, pain behind the eyes, muscle and joint pains, nausea, vomiting, swollen glands and rash. Severe dengue is a potentially fatal complication, due to plasma leaking, fluid accumulation, respiratory distress, severe bleeding or organ impairment. Dengue virus does not usually cause neurological manifestations, unlike other arboviral infections. Encephalopathy is the most common neurological complication. Encephalitis is rare manifestation. We report a rare case of dengue encephalitis from Pakistan, with extensive brain lesions involving the thalamus, cerebellar vermis and frontoparietal periventricular regions. Therefore, we suggest dengue encephalitis should be considered in the differential diagnosis of fever with altered sensorium, especially in Asian countries such as Pakistan where dengue is rampant as dengue encephalitis can be fatal at times.
摘要：
登革热感染在包括巴基斯坦在内的129个国家很常见，估计每年有3.9亿例登革热病毒感染。亚洲占实际负担的70%。登革热的临床体征和症状包括高烧（40°C/104°F），在高热阶段伴有以下两种症状：严重头痛，眼睛后面的疼痛，肌肉和关节疼痛，恶心,呕吐,腺体肿胀和皮疹.严重的登革热是一种潜在的致命并发症，由于等离子体泄漏，流体积聚,呼吸窘迫,严重出血或器官损伤。登革热病毒通常不会引起神经系统表现，与其他虫媒病毒感染不同。脑病是最常见的神经系统并发症。脑炎是罕见的表现。我们报道了一个来自巴基斯坦的罕见登革热脑炎病例，涉及丘脑的广泛脑损伤，小脑疣和额叶脑室周围区域。因此,我们建议登革热脑炎应考虑在鉴别诊断有感觉改变的发热，特别是在亚洲国家，如巴基斯坦，登革热猖獗，因为登革热脑炎有时可能致命。
