PDF(Pubmed)
Abstract：
UNASSIGNED: The Mycobacterium tuberculosis complex causes tuberculosis, a severe public health problem. Close contacts of someone who has active pulmonary tuberculosis were at a greater risk of contracting the disease. Despite the large number of primary research available in Sub-Saharan African nations, there are no systematic reviews or meta-analyses that estimate the pooled prevalence of tuberculosis among tuberculosis patients\' household contacts (HHC). Thus, this study aimed to estimate the pooled prevalence of tuberculosis in a household contact of tuberculosis patients in the sub-Saharan African region.
UNASSIGNED: Potential papers were systematically searched from electronic databases (PubMed, Google scholar and web of science). To analyze the quality of the papers featured, we used the Joanna Briggs Institute Critical Appraisal methods. Data were analyzed using STATA Version 16.
UNASSIGNED: After screening 373 studies, the final analysis includes 20 articles from twelve countries. The overall prevalence of tuberculosis among household contacts was 3.29 % (95 % CI; 2.35 %-4.23 %). The overall prevalence rate of active tuberculosis in children aged less than five years was 2.60 % (95 % CI; 1.81 %-3.39 %). When the index patient age was less than 18 years old, the pooled prevalence of active TB in HHC was 2.64 % (95 % CI; 1.46 %-3.81 %). The pooled proportion of HIV in index TB patients was 53.12 % (95 % CI, 39.73 %-66.51 %). The overall pooled prevalence of HIV in household contacts was 7.75 % (95 % CI, 4.21 %-11.29 %).
UNASSIGNED: Our systematic review showed that, in Sub-Saharan African nations, household contacts are at a high risk of contracting tuberculosis from their index patient. According to this study, one out of every thirty household contacts will develop active tuberculosis. This demonstrated the significance of doing thorough active tuberculosis case tracing in household contacts to locate missing tuberculosis patients.
UNASSIGNED: Potential papers were systematically searched from electronic databases (PubMed, Google scholar and web of science). To analyze the quality of the papers featured, we used the Joanna Briggs Institute Critical Appraisal methods. Data were analyzed using STATA Version 16.
UNASSIGNED: After screening 373 studies, the final analysis includes 20 articles from twelve countries. The overall prevalence of tuberculosis among household contacts was 3.29 % (95 % CI; 2.35 %-4.23 %). The overall prevalence rate of active tuberculosis in children aged less than five years was 2.60 % (95 % CI; 1.81 %-3.39 %). When the index patient age was less than 18 years old, the pooled prevalence of active TB in HHC was 2.64 % (95 % CI; 1.46 %-3.81 %). The pooled proportion of HIV in index TB patients was 53.12 % (95 % CI, 39.73 %-66.51 %). The overall pooled prevalence of HIV in household contacts was 7.75 % (95 % CI, 4.21 %-11.29 %).
UNASSIGNED: Our systematic review showed that, in Sub-Saharan African nations, household contacts are at a high risk of contracting tuberculosis from their index patient. According to this study, one out of every thirty household contacts will develop active tuberculosis. This demonstrated the significance of doing thorough active tuberculosis case tracing in household contacts to locate missing tuberculosis patients.
摘要：
未经证实：结核分枝杆菌复合体导致结核病，严重的公共卫生问题。患有活动性肺结核的人的密切接触者感染该病的风险更大。尽管撒哈拉以南非洲国家有大量的初步研究，目前尚无系统综述或荟萃分析来评估结核病患者家庭接触者(HHC)中结核病的合并患病率.因此，本研究旨在评估撒哈拉以南非洲地区一名家庭接触结核病患者的合并结核病患病率.
UNASSIGNED：从电子数据库中系统地搜索了潜在的论文（PubMed，谷歌学者和科学网)。为了分析论文的质量，我们使用了乔安娜·布里格斯研究所的批判性评估方法。使用STATA版本16分析数据。
未经评估：筛选373项研究后，最终分析包括来自十二个国家的20篇文章。家庭接触者中结核病的总体患病率为3.29%(95%CI;2.35%-4.23%)。5岁以下儿童活动性肺结核总患病率为2.60%(95%CI;1.81%-3.39%)。当指数患者年龄小于18岁时，HHC中活动性TB的合并患病率为2.64%(95%CI;1.46%-3.81%).结核病指数患者中HIV的合并比例为53.12％（95％CI，39.73％-66.51％）。家庭接触者中HIV的总体汇总患病率为7.75％（95％CI，4.21％-11.29％）。
未经评估：我们的系统审查表明，在撒哈拉以南非洲国家，家庭接触者与他们的索引患者感染结核病的风险很高。根据这项研究,每30个家庭接触者中就有一个会患上活动性结核病。这证明了在家庭接触者中进行彻底的主动结核病病例追踪以定位失踪的结核病患者的重要性。
UNASSIGNED：从电子数据库中系统地搜索了潜在的论文（PubMed，谷歌学者和科学网)。为了分析论文的质量，我们使用了乔安娜·布里格斯研究所的批判性评估方法。使用STATA版本16分析数据。
未经评估：筛选373项研究后，最终分析包括来自十二个国家的20篇文章。家庭接触者中结核病的总体患病率为3.29%(95%CI;2.35%-4.23%)。5岁以下儿童活动性肺结核总患病率为2.60%(95%CI;1.81%-3.39%)。当指数患者年龄小于18岁时，HHC中活动性TB的合并患病率为2.64%(95%CI;1.46%-3.81%).结核病指数患者中HIV的合并比例为53.12％（95％CI，39.73％-66.51％）。家庭接触者中HIV的总体汇总患病率为7.75％（95％CI，4.21％-11.29％）。
未经评估：我们的系统审查表明，在撒哈拉以南非洲国家，家庭接触者与他们的索引患者感染结核病的风险很高。根据这项研究,每30个家庭接触者中就有一个会患上活动性结核病。这证明了在家庭接触者中进行彻底的主动结核病病例追踪以定位失踪的结核病患者的重要性。
