PDF(Pubmed)
Abstract：
Antibiotics, the most frequently prescribed drugs, have been widely applied to prevent or cure human and veterinary diseases and have undoubtedly led to massive releases into sewer networks and wastewater treatment systems, a hotspot where the occurrence and transformation of antibiotic resistance take place. Extracellular polymeric substances (EPS), biopolymers secreted via microbial activity, play an important role in cell adhesion, nutrient retention, and toxicity resistance. However, the potential roles of sludge EPS related to the resistance and removal of antibiotics are still unclear. This work summarizes the composition and physicochemical characteristics of state-of-the-art microbial EPS, highlights the critical role of EPS in antibiotics removal, evaluates their defense performances under different antibiotics exposures, and analyzes the typical factors that could affect the sorption and biotransformation behavior of antibiotics. Next, interactions between microbial EPS and antibiotic resistance genes are analyzed. Future perspectives, especially the engineering application of microbial EPS for antibiotics toxicity detection and defense, are also emphatically stressed.
摘要：
抗生素,最常用的处方药，已广泛应用于预防或治疗人类和兽医疾病，无疑导致大量排放到下水道网络和废水处理系统，抗生素耐药性发生和转化的热点。细胞外聚合物（EPS），通过微生物活性分泌的生物聚合物，在细胞粘附中起重要作用，营养保留，和毒性抗性。然而,污泥EPS与抗生素的耐药性和去除有关的潜在作用尚不清楚。这项工作总结了最先进的微生物EPS的组成和物理化学特性，强调了EPS在抗生素去除中的关键作用，评估他们在不同抗生素暴露下的防御性能，并分析了影响抗生素吸附和生物转化行为的典型因素。接下来,分析了微生物EPS与抗生素抗性基因之间的相互作用。未来的前景,特别是微生物EPS在抗生素毒性检测和防御中的工程应用，也着重强调。
