PDF(Pubmed)
Abstract：
UNASSIGNED: Kidney cancer accounted for 1. 8% of global cancer deaths according to Globocan 2020 estimates, with most of these being renal cell carcinomas. Lower rates of renal cell carcinoma are reported for Africa and these are expected to change for a combination of reasons. The clinical and morphologic characteristics of renal cell carcinoma seen within Kenya have not been described before. This study aims to partially fill this gap.
UNASSIGNED: This was a cross-sectional descriptive study examining electronic histopathology reports from the Aga Khan University Hospital Nairobi Laboratory for the period January 2016 to May 2022.
UNASSIGNED: Sixty cases of renal cell carcinoma were identified. The mean age at diagnosis was 55.3 years. The most common histologic subtype diagnosed was clear cell renal cell carcinoma (41.7%), followed by papillary renal cell carcinoma and renal cell carcinoma not further specified (both 21.7%), and chromophobe renal cell carcinoma (11.7%). The most frequent specimen type was resection, followed by cores of renal masses. The mean tumor size was 8.5 cm. Sixty-seven percent of patients presented with Stage III and above.
UNASSIGNED: Renal masses were the commonest clinical indication for biopsy among the records reviewed. The male to female ratio, as well as the mean age at presentation were comparable to what is described in literature for other regions of the world. The proportions of the commonest histologic subtypes matched what is described in other parts of the world. Challenges in the identification of histologic subtypes included having a limited panel of antibodies for diagnosis and the lack of genetic molecular tests for histotyping.
UNASSIGNED: The spectrum of histologic subtypes of renal cell carcinoma seen at a tertiary referral hospital in Nairobi, Kenya was similar to that described in other parts of Africa and the globe. The age at presentation with renal cell carcinoma was consistent with what has been described in literature. Challenges were identified in the accurate histotyping of renal cell carcinoma due to constrained resources. Majority of cases diagnosed presented at advanced stage.
UNASSIGNED: This was a cross-sectional descriptive study examining electronic histopathology reports from the Aga Khan University Hospital Nairobi Laboratory for the period January 2016 to May 2022.
UNASSIGNED: Sixty cases of renal cell carcinoma were identified. The mean age at diagnosis was 55.3 years. The most common histologic subtype diagnosed was clear cell renal cell carcinoma (41.7%), followed by papillary renal cell carcinoma and renal cell carcinoma not further specified (both 21.7%), and chromophobe renal cell carcinoma (11.7%). The most frequent specimen type was resection, followed by cores of renal masses. The mean tumor size was 8.5 cm. Sixty-seven percent of patients presented with Stage III and above.
UNASSIGNED: Renal masses were the commonest clinical indication for biopsy among the records reviewed. The male to female ratio, as well as the mean age at presentation were comparable to what is described in literature for other regions of the world. The proportions of the commonest histologic subtypes matched what is described in other parts of the world. Challenges in the identification of histologic subtypes included having a limited panel of antibodies for diagnosis and the lack of genetic molecular tests for histotyping.
UNASSIGNED: The spectrum of histologic subtypes of renal cell carcinoma seen at a tertiary referral hospital in Nairobi, Kenya was similar to that described in other parts of Africa and the globe. The age at presentation with renal cell carcinoma was consistent with what has been described in literature. Challenges were identified in the accurate histotyping of renal cell carcinoma due to constrained resources. Majority of cases diagnosed presented at advanced stage.
摘要：
未经证实：肾癌占1。根据Globocan2020年的估计，全球癌症死亡人数占8%，其中大多数是肾细胞癌。据报道，非洲的肾细胞癌发生率较低，并且由于多种原因，预计这些变化会发生变化。以前没有描述过在肯尼亚所见的肾细胞癌的临床和形态学特征。本研究旨在部分填补这一空白。
UNASSIGNED：这是一项横断面描述性研究，检查了2016年1月至2022年5月阿加汗大学医院内罗毕实验室的电子组织病理学报告。
未经证实：共60例肾细胞癌。诊断时的平均年龄为55.3岁。最常见的组织学亚型诊断为透明细胞肾细胞癌（41.7%），其次是乳头状肾细胞癌和未进一步说明的肾细胞癌（均为21.7％），肾嫌色细胞癌(11.7%)。最常见的标本类型是切除，其次是肾脏肿块的核心。平均肿瘤大小为8.5cm。67%的患者出现III期及以上。
未经批准：在所审查的记录中，肾肿块是最常见的活检临床指征。男女比例，以及演示时的平均年龄与世界其他地区的文献中描述的相当。最常见的组织学亚型的比例与世界其他地区所描述的相匹配。组织学亚型鉴定方面的挑战包括具有有限的用于诊断的抗体组和缺乏用于组织分型的遗传分子测试。
未经证实：在内罗毕一家三级转诊医院看到的肾细胞癌的组织学亚型谱，肯尼亚与非洲和全球其他地区的情况相似。出现肾细胞癌的年龄与文献中描述的年龄一致。由于资源有限，在肾细胞癌的准确组织分型中发现了挑战。大多数病例诊断为晚期。
UNASSIGNED：这是一项横断面描述性研究，检查了2016年1月至2022年5月阿加汗大学医院内罗毕实验室的电子组织病理学报告。
未经证实：共60例肾细胞癌。诊断时的平均年龄为55.3岁。最常见的组织学亚型诊断为透明细胞肾细胞癌（41.7%），其次是乳头状肾细胞癌和未进一步说明的肾细胞癌（均为21.7％），肾嫌色细胞癌(11.7%)。最常见的标本类型是切除，其次是肾脏肿块的核心。平均肿瘤大小为8.5cm。67%的患者出现III期及以上。
未经批准：在所审查的记录中，肾肿块是最常见的活检临床指征。男女比例，以及演示时的平均年龄与世界其他地区的文献中描述的相当。最常见的组织学亚型的比例与世界其他地区所描述的相匹配。组织学亚型鉴定方面的挑战包括具有有限的用于诊断的抗体组和缺乏用于组织分型的遗传分子测试。
未经证实：在内罗毕一家三级转诊医院看到的肾细胞癌的组织学亚型谱，肯尼亚与非洲和全球其他地区的情况相似。出现肾细胞癌的年龄与文献中描述的年龄一致。由于资源有限，在肾细胞癌的准确组织分型中发现了挑战。大多数病例诊断为晚期。
