Abstract：
Monitoring O2 and pH has excellent potential in different sensing applications, especially in biological and clinical applications. This report presents a protocol for synthesizing an optical dual nanosensor for those two parameters. The organically modified silica (ormosil) nanoparticles were prepared based on phenytrimethoxysilane in an aqueous solution using an acid-base one-pot strategy. Ormosil was selected as a lipophilic matrix for loading fluorescent O2-sensitive dye platinum(II)-tetrakis-(pentafluorophenyl) porphyrin (Pt-TPFPP), which was quenched in the presence of O2 gas and exhibited a considerable detection proficiency within a percentage range of (0-100%) O2. Commercially available drug ingredient salicylamide was labeled on the surface of the nanoparticles using a coupling agent (3-glycidoxypropyl) trimethoxysilane (GPTMS). For measuring pH, salicylamide acted for the first time as a pH-sensitive probe based on a turn-on process with increasing pH. The nanosensor displayed a significant pH detection efficiency in the range of (pH = 6-10). Salicylamide turn-on fluorescence was attributed to the excited state intramolecular transfer (ESIPT) process followed by the inter charge transfer (ICT). The presented dual nanosensor opens new opportunities as a promising candidate material for industrial systems and medical applications.
摘要：
监测O2和pH在不同的传感应用中具有出色的潜力，尤其是在生物和临床应用中。该报告提出了针对这两个参数合成光学双纳米传感器的协议。有机改性的二氧化硅（ormosil）纳米颗粒是基于苯基三甲氧基硅烷在水溶液中使用酸碱一锅法制备的。选择Ormosil作为负载荧光O2敏感染料铂（II）-四（五氟苯基）卟啉（Pt-TPFPP）的亲脂性基质，在O2气体存在下淬火，并在（0-100％）O2的百分比范围内表现出相当大的检测能力。使用偶联剂(3-环氧丙氧丙基)三甲氧基硅烷(GPTMS)在纳米颗粒的表面上标记市售药物成分水杨酰胺。测量pH值,基于pH增加的开启过程，水杨酰胺首次用作pH敏感探针。纳米传感器在（pH=6-10）范围内显示出显着的pH检测效率。水杨酸酰胺的开启荧光归因于激发态分子内转移（ESIPT）过程，然后是电荷转移（ICT）。所提出的双纳米传感器作为工业系统和医疗应用的有希望的候选材料开辟了新的机会。
