PDF(Pubmed)
Abstract：
Posttraumatic stress disorder (PTSD) is a disorder with chronic deterioration that arises after exposure to traumatic events. In these events, a persistent maladaptive reaction was found as a result of severe psychological stress and trauma. It is usually accompanied by mood alteration, disturbing memories, evading behavior, and hyperarousal. Many studies found a connection between PTSD and both ischemic heart disease (IHD) and atrial fibrillation (AF). Impairment of the hypothalamic-pituitary-adrenal axis and sympathetic nervous system can contribute to hypercoagulability, elevated cardiac reactivity, hypertension, dyslipidemia, and chronic inflammation, as all of these processes are implicated in IHD and AF risk. PTSD tends to have a more long-term course and is associated with more autonomic reactivity rather than a direct negative impact. More research is needed to understand the mechanisms underlying the increased AF risk in patients with PTSD and to identify supposed objectives for screening, intervention, and treatment. Highlighting the connection between PTSD and cardiovascular events would lead clinicians to develop screening tests that might help with the prevention and treatment of cardiovascular events for these patients.
摘要：
创伤后应激障碍（PTSD）是一种在暴露于创伤事件后出现的慢性恶化的疾病。在这些事件中,由于严重的心理压力和创伤，发现了持续的适应不良反应。它通常伴随着情绪的改变，令人不安的记忆,逃避行为，和过度觉醒。许多研究发现PTSD与缺血性心脏病（IHD）和心房颤动（AF）之间存在联系。下丘脑-垂体-肾上腺轴和交感神经系统受损可导致高凝状态，心脏反应性升高,高血压,血脂异常,和慢性炎症，因为所有这些过程都与IHD和AF风险有关。PTSD往往具有更长期的病程，并且与更多的自主神经反应性有关，而不是直接的负面影响。需要更多的研究来了解PTSD患者房颤风险增加的潜在机制，并确定筛查的假定目标。干预，和治疗。强调PTSD和心血管事件之间的联系将导致临床医生开发筛查测试，这可能有助于预防和治疗这些患者的心血管事件。
