Abstract：
Alterations to the LRRK2 gene have been associated with Parkinson\'s disease and alcohol consumption in animals and humans. Furthermore, these disorders are strongly related to anxiety disorders (ADs). Thus, we investigated how the LRRK2 gene might influence anxiety in humans and mice. We elaborated a systematic review based on the PRISMA Statement of studies that investigated levels of anxiety in animal or human models with alterations in the LRRK2 gene. The search was conducted in the PubMed, Scopus, and Web of Science databases, and in reference lists with descriptors related to ADs and the LRRK2. From the 62 articles assessed for eligibility, 16 were included: 11 conducted in humans and seven, in mice. Lrrk2 KO mice and the LRRK2 G2019S, LRRK2 R1441G, and LRRK2 R1441C variants were addressed. Five articles reported an increase in anxiety levels concerning the LRRK2 variants. Decreased anxiety levels were observed in two articles, one focusing on the LRRK2 G2019S and the other, on the Lrrk2 KO mice. Eight other articles reported no differences in anxiety levels in individuals with Lrrk2 alterations compared to their healthy controls. This study discusses a possible influence between the LRRK2 gene and anxiety, adding information to the existing knowledge respecting the influence of genetics on anxiety.
摘要：
LRRK2基因的改变与动物和人类的帕金森病和饮酒有关。此外，这些疾病与焦虑症（AD）密切相关。因此，我们研究了LRRK2基因如何影响人类和小鼠的焦虑。我们根据PRISMA研究声明进行了系统综述，该研究调查了LRRK2基因改变的动物或人体模型中的焦虑水平。搜索是在PubMed中进行的，Scopus,和WebofScience数据库,并且在具有与AD和LRRK2相关的描述符的参考列表中。从评估资格的62篇文章中，包括16个：11个在人类中进行，7个，在老鼠身上。Lrrk2KO小鼠和LRRK2G2019S，LRRK2R1441G,和LRRRK2R1441C变体得到解决。五篇文章报道了有关LRRK2变体的焦虑水平增加。在两篇文章中观察到焦虑水平降低，一个专注于LRRK2G2019S，另一个专注于LRRK2G2019S，在Lrrk2KO小鼠上。其他八篇文章报道，与健康对照组相比，Lrrk2改变的个体的焦虑水平没有差异。这项研究讨论了LRRK2基因和焦虑之间可能的影响，在现有知识中增加信息，尊重遗传学对焦虑的影响。
