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Abstract：
UNASSIGNED: Polycystic ovary syndrome (PCOS) is commonest endocrine disease occurring in women of reproductive age. This study conducted to clarify altered concentrations of Nesfatin-1, nicotinamide adenine dinucleotide phosphate (NADPH), and dopamine in PCOS women and controls. Also, to assess their role in PCOS pathophysiology and their correlation with measured biochemical parameters.
UNASSIGNED: In this observational study, 60 PCOS patients and 24 controls included. Medical history was recorded and full examinations were done. Serum concentrations of lipid profile, fasting blood glucose (FBG), fasting insulin (FSI), luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, testosterone, progesterone, estradiol, Nesfatin-1, dopamine, and NADPH were measured by ELISA kits. Values were analyzed using unpaired t-test and Pearson Chi-square test. The p<0.05 was considered statistically significant.
UNASSIGNED: In this study, there was significantly elevated waist hip ratio (WHR) and body mass index (BMI) in PCOS patients versus controls (p<0.0001 and p=0.014). There was significant increase in FSH, LH, prolactin, estradiol, testosterone, Nesfatin-1, and dopamine (p=0.021, p=0.015, p<0.0001, p<0.0001, p=0.006, p=0.017, p< 0.0001) and decrease of NADPH (p<0.0001) in PCOS patients. There were significant positive correlations between Nesfatin-1, prolactin, and dopamine levels. Also, there was significant positive correlation between dopamine and BMI, FSI, FSH, LH, estradiol, and prolactin levels; however, significant negative correlations observed between NADPH and BMI, FSI, estradiol, and prolactin levels.
UNASSIGNED: Elevated serum Nesfatin-1 concentrations and their association with hyperprolactinemia indicate that they have a role in PCOS pathophysiology. Moreover, elevated dopamine and decreased NADPH concentrations could play role in PCOS pathogenesis.
UNASSIGNED: In this observational study, 60 PCOS patients and 24 controls included. Medical history was recorded and full examinations were done. Serum concentrations of lipid profile, fasting blood glucose (FBG), fasting insulin (FSI), luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, testosterone, progesterone, estradiol, Nesfatin-1, dopamine, and NADPH were measured by ELISA kits. Values were analyzed using unpaired t-test and Pearson Chi-square test. The p<0.05 was considered statistically significant.
UNASSIGNED: In this study, there was significantly elevated waist hip ratio (WHR) and body mass index (BMI) in PCOS patients versus controls (p<0.0001 and p=0.014). There was significant increase in FSH, LH, prolactin, estradiol, testosterone, Nesfatin-1, and dopamine (p=0.021, p=0.015, p<0.0001, p<0.0001, p=0.006, p=0.017, p< 0.0001) and decrease of NADPH (p<0.0001) in PCOS patients. There were significant positive correlations between Nesfatin-1, prolactin, and dopamine levels. Also, there was significant positive correlation between dopamine and BMI, FSI, FSH, LH, estradiol, and prolactin levels; however, significant negative correlations observed between NADPH and BMI, FSI, estradiol, and prolactin levels.
UNASSIGNED: Elevated serum Nesfatin-1 concentrations and their association with hyperprolactinemia indicate that they have a role in PCOS pathophysiology. Moreover, elevated dopamine and decreased NADPH concentrations could play role in PCOS pathogenesis.
摘要：
未经证实：多囊卵巢综合征（PCOS）是发生在育龄妇女中最常见的内分泌疾病。本研究旨在阐明Nesfatin-1，烟酰胺腺嘌呤二核苷酸磷酸（NADPH）的浓度变化，PCOS女性和对照组的多巴胺。此外，评估它们在PCOS病理生理中的作用及其与测得的生化参数的相关性。
未经评估：在这项观察性研究中，包括60名PCOS患者和24名对照。记录病史并进行全面检查。血脂谱的血清浓度，空腹血糖（FBG），空腹胰岛素（FSI），黄体生成素(LH),卵泡刺激素（FSH），催乳素,睾丸激素，黄体酮,雌二醇,Nesfatin-1多巴胺,用ELISA试剂盒测定NADPH。使用非配对t检验和Pearson卡方检验分析值。p<0.05被认为是统计学上显著的。
未经批准：在这项研究中，与对照组相比,PCOS患者的腰臀比(WHR)和体重指数(BMI)显著升高(p<0.0001和p=0.014).FSH显著增加,LH,催乳素,雌二醇,睾丸激素，Nesfatin-1和多巴胺（p=0.021，p=0.015，p<0.0001，p<0.0001，p=0.006，p=0.017，p<0.0001）和NADPH降低（p<0.0001）。Nesfatin-1、催乳素、和多巴胺水平。此外，多巴胺与BMI呈显著正相关,FSI,FSH,LH,雌二醇,和催乳素水平；然而，在NADPH和BMI之间观察到显着的负相关，FSI,雌二醇,和催乳素水平。
未经证实：血清Nesfatin-1浓度升高及其与高催乳素血症的相关性表明它们在PCOS病理生理学中具有作用。此外，多巴胺升高和NADPH浓度降低可能在PCOS发病中发挥作用。
未经评估：在这项观察性研究中，包括60名PCOS患者和24名对照。记录病史并进行全面检查。血脂谱的血清浓度，空腹血糖（FBG），空腹胰岛素（FSI），黄体生成素(LH),卵泡刺激素（FSH），催乳素,睾丸激素，黄体酮,雌二醇,Nesfatin-1多巴胺,用ELISA试剂盒测定NADPH。使用非配对t检验和Pearson卡方检验分析值。p<0.05被认为是统计学上显著的。
未经批准：在这项研究中，与对照组相比,PCOS患者的腰臀比(WHR)和体重指数(BMI)显著升高(p<0.0001和p=0.014).FSH显著增加,LH,催乳素,雌二醇,睾丸激素，Nesfatin-1和多巴胺（p=0.021，p=0.015，p<0.0001，p<0.0001，p=0.006，p=0.017，p<0.0001）和NADPH降低（p<0.0001）。Nesfatin-1、催乳素、和多巴胺水平。此外，多巴胺与BMI呈显著正相关,FSI,FSH,LH,雌二醇,和催乳素水平；然而，在NADPH和BMI之间观察到显着的负相关，FSI,雌二醇,和催乳素水平。
未经证实：血清Nesfatin-1浓度升高及其与高催乳素血症的相关性表明它们在PCOS病理生理学中具有作用。此外，多巴胺升高和NADPH浓度降低可能在PCOS发病中发挥作用。
