PDF(Pubmed)
Abstract：
The use of antimalarial drugs for prophylaxis is a widespread practice while traveling to underdeveloped nations, particularly those with a high malaria prevalence. Chloroquine is still one of the most commonly recommended antimalarials, either alone or in combination with others, for prophylaxis. However, its increased use over the past few decades has been associated with many adverse effects, including headaches, dizziness, vomiting, and diarrhea, as well as neuropsychiatric symptoms such as psychosis. Here, we discuss the case of a 30-year-old Asian man who, after starting a 500-milligram (mg) prophylactic dosage of chloroquine per week, developed psychotic symptoms. This case highlights the need to use chloroquine and other antimalarials with care, especially when beginning as a prophylactic measure with the lowest suggested dosage.
摘要：
在前往不发达国家时，使用抗疟药进行预防是一种普遍的做法，特别是那些疟疾流行率很高的人。氯喹仍然是最常用的抗疟药之一，无论是单独还是与他人结合，用于预防。然而,在过去的几十年中，它的使用增加了许多不利影响，包括头痛,头晕,呕吐,腹泻,以及精神病等神经精神症状。这里,我们讨论了一个30岁的亚洲男人的案子，在开始每周500毫克（mg）氯喹的预防剂量后，出现精神病症状.这种情况突出表明需要小心使用氯喹和其他抗疟药，特别是当开始作为预防措施与最低的建议剂量。
