Abstract：
Due to the unavailability of donors, the use of left ventricular assist devices has emerged to be a reliable line of alternative treatment for heart failure. However, ventricular assist devices (VAD) have been associated with several postoperative complications such as thrombosis, hemolysis, etc. Despite considerable improvements in technology, blood trauma due to high shear stress generation has been a major concern that is largely related to the geometrical feature of the VAD. This study aims to establish the design process of a centrifugal pump by considering several variations in the geometrical feature of a base design using the commercial solver ANSYS-CFX. To capture the uncertain behavior of blood as fluid, Newtonian, as well as non-Newtonian (Bird-Carreau model), models are used for flow field prediction. To assess the possibility of blood damage maximum wall shear stress and hemolysis index have been estimated for each operating point. The results of the simulations yield an optimized design of the pump based on parameters like pressure head generation, maximum shear stress, hydraulic efficiency, and hemolysis index. Further, the design methodology and the steps of development discussed in the paper can serve as a guideline for developing small centrifugal pumps handling blood.
摘要：
由于捐助者无法获得，左心室辅助装置的使用已成为心力衰竭替代治疗的可靠途径.然而,心室辅助装置（VAD）与一些术后并发症有关，如血栓形成，溶血,等。尽管技术有了很大的进步，由于高剪切应力的产生而引起的血液创伤一直是一个主要问题，这在很大程度上与VAD的几何特征有关。本研究旨在通过考虑使用商业求解器ANSYS-CFX的基础设计的几何特征的几种变化来建立离心泵的设计过程。为了捕捉血液作为液体的不确定行为，牛顿,以及非牛顿(Bird-Carreau模型)，模型用于流场预测。为了评估血液损伤的可能性，已经估计了每个操作点的最大壁切应力和溶血指数。模拟结果根据压力头生成等参数对泵进行了优化设计，最大剪应力,水力效率,和溶血指数。Further,本文讨论的设计方法和开发步骤可以作为开发处理血液的小型离心泵的指南。
