PDF(Pubmed)
Abstract：
UNASSIGNED: Whether administration of antispasmodics as a component of premedication contributes to detection of lesions by screening esophagogastroduodenoscopy (EGDS) remains unclear. Our primary aim was to investigate this possibility.
UNASSIGNED: The cohort in this retrospective study comprised consecutive asymptomatic individuals who had undergone screening EGDS as part of a health check-up at the Japanese Red Cross Wakayama Medical Center from October 2015 to September 2020. The investigated lesions comprised esophageal squamous cell carcinoma or adenocarcinoma, gastric adenoma or adenocarcinoma, and duodenal adenoma or adenocarcinoma.
UNASSIGNED: Targeted lesions were detected in 72 of 31 484 participants (0.23%), 18 260 and 13 224 of whom had received and not received pre-procedure antispasmodics, respectively. The rates of detection of lesions in these groups were 0.21% (38/18260) and 0.26% (34/13224), respectively (P = 0.40). Multivariate logistic regression analysis showed no association between administration of antispasmodics and rates of detection of targeted lesions [P = 0.24, Odds ratio (95% CI): 1.46 (0.78-2.75)].
UNASSIGNED: Antispasmodics, which were administered to more than half of the study cohort, did not improve the rate of detection of targeted lesions.
UNASSIGNED: The cohort in this retrospective study comprised consecutive asymptomatic individuals who had undergone screening EGDS as part of a health check-up at the Japanese Red Cross Wakayama Medical Center from October 2015 to September 2020. The investigated lesions comprised esophageal squamous cell carcinoma or adenocarcinoma, gastric adenoma or adenocarcinoma, and duodenal adenoma or adenocarcinoma.
UNASSIGNED: Targeted lesions were detected in 72 of 31 484 participants (0.23%), 18 260 and 13 224 of whom had received and not received pre-procedure antispasmodics, respectively. The rates of detection of lesions in these groups were 0.21% (38/18260) and 0.26% (34/13224), respectively (P = 0.40). Multivariate logistic regression analysis showed no association between administration of antispasmodics and rates of detection of targeted lesions [P = 0.24, Odds ratio (95% CI): 1.46 (0.78-2.75)].
UNASSIGNED: Antispasmodics, which were administered to more than half of the study cohort, did not improve the rate of detection of targeted lesions.
摘要：
UNASSIGNED：作为术前用药组成部分的抗痉挛药是否有助于通过食管胃十二指肠镜检查（EGDS）筛查来检测病变尚不清楚。我们的主要目的是调查这种可能性。
UNASSIGNED：这项回顾性研究中的队列包括2015年10月至2020年9月在日本和歌山红十字会医学中心接受EGDS筛查的连续无症状个体。调查的病变包括食管鳞状细胞癌或腺癌，胃腺瘤或腺癌，十二指肠腺瘤或腺癌。
UNASSIGNED：在31484名参与者中的72名（0.23％）中检测到目标病变，18260人和13224人接受和未接受术前抗菌药物，分别。这些组的病灶检出率分别为0.21%(38/18260)和0.26%(34/13224),分别为(P=0.40)。多因素logistic回归分析显示，抗痉挛药的给药与目标病变的检出率之间无相关性[P=0.24，赔率比（95％CI）：1.46（0.78-2.75）]。
未经授权：防痉挛药，超过一半的研究队列中使用了这些药物，没有提高靶向病变的检出率。
UNASSIGNED：这项回顾性研究中的队列包括2015年10月至2020年9月在日本和歌山红十字会医学中心接受EGDS筛查的连续无症状个体。调查的病变包括食管鳞状细胞癌或腺癌，胃腺瘤或腺癌，十二指肠腺瘤或腺癌。
UNASSIGNED：在31484名参与者中的72名（0.23％）中检测到目标病变，18260人和13224人接受和未接受术前抗菌药物，分别。这些组的病灶检出率分别为0.21%(38/18260)和0.26%(34/13224),分别为(P=0.40)。多因素logistic回归分析显示，抗痉挛药的给药与目标病变的检出率之间无相关性[P=0.24，赔率比（95％CI）：1.46（0.78-2.75）]。
未经授权：防痉挛药，超过一半的研究队列中使用了这些药物，没有提高靶向病变的检出率。
