Apropos of menstrual changes and abnormal uterine bleeding after COVID-19 vaccination.

COVID - 19 疫苗接种后月经变化和异常子宫出血的相关性。

• 发表时间: Nov 2022 8
• 来源期刊: Brain Hemorrhages
• DOI: 10.1016/j.hest.2022.11.001
• PMID: 36406341
• 文章类型: Journal Article
• 作者列表: Roncati L,Manenti A

关键词: Abnormal uterine bleeding; Adenohypophysis microcirculation; CD31, cluster of differentiation 31; COVID-19 vaccination; COVID-19, coronavirus disease 2019; Coronavirus disease 2019 (COVID-19); EMA, European Medicines Agency; Fenestrated capillaries; Heavy menstrual bleeding; Menstrual changes; PA, pituitary apoplexy; PRAC, Pharmacovigilance Risk Assessment Committee; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2); modRNA, nucleoside-modified messenger ribonucleic acid

Abstract

It is news of 28 October 2022 that the Pharmacovigilance Risk Assessment Committee of the European Medicines Agency has recommended to add heavy menstrual bleeding among the side effects of unknown frequency inside the package insert of nucleoside-modified messenger ribonucleic acid vaccines to prevent coronavirus disease 2019 (COVID-19). The decision has been made in the light of the numerous reports of unexpected menstrual changes or abnormal uterine bleeding following COVID-19 vaccination. Here we advance a possible involvement of the particular adenohypophyseal microcirculation in these strange and still unexplained events.

摘要

2022年10月28日的消息是，欧洲药品管理局药物警戒风险评估委员会建议在核苷修饰的信使核糖核酸疫苗包装插页中增加严重月经出血，以预防冠状病毒病2019（COVID-19）。这一决定是根据大量关于COVID-19疫苗接种后意外月经变化或异常子宫出血的报道做出的。在这里，我们提出了这些奇怪且仍无法解释的事件中特定腺垂体微循环的可能参与。