PDF(Pubmed)
Abstract：
UNASSIGNED: Human monkeypox, a zoonosis historically endemic to West and South Africa, has led to a worldwide outbreak driven by human-to-human transmission resulting in an international public health emergency. Endemic and outbreak monkeypox cases may differ in their affected populations, clinical features, and outcomes. Thus, profiling cases of the current monkeypox outbreak worldwide is crucial.
UNASSIGNED: We performed a nationwide observational surveillance-based study from May 24 to September 5, 2022. Patients that met the operational clinical definition of monkeypox or symptomatic close contacts of confirmed cases were tested by real-time polymerase chain reaction. Clinical data were collected with a standardized case-report form. We report epidemiologic, sociodemographic, and clinical characteristics of confirmed cases.
UNASSIGNED: Five-hundred and sixty-five human monkeypox confirmed cases were analysed; 97.2% were men, of whom 59.5% identified as men who have sex with men, and 54.5% had human immunodeficiency virus infection. The median age was 34 years. All patients but one had rash (99.8%), 78.9% had fever, and 47.8% reported myalgia. The anogenital area was the most commonly affected one by rash (49.6%), and proctitis occurred in 6.2% of patients. Six patients required hospitalization, of which one died due to causes unrelated to monkeypox.
UNASSIGNED: The 2022 monkeypox outbreak in Mexico is mainly driven by middle-aged men who have sex with men, of which a large proportion are persons who live with human immunodeficiency virus infection. Clinical features such as the high proportion of anogenital lesions suggest sexual contact is a pivotal transmission mechanism in this outbreak.
UNASSIGNED: This research was supported by grant A1-S-18342 from Consejo Nacional de Ciencia y Tecnología (CONACyT), Mexico (to S.I.V.-F.).
UNASSIGNED: We performed a nationwide observational surveillance-based study from May 24 to September 5, 2022. Patients that met the operational clinical definition of monkeypox or symptomatic close contacts of confirmed cases were tested by real-time polymerase chain reaction. Clinical data were collected with a standardized case-report form. We report epidemiologic, sociodemographic, and clinical characteristics of confirmed cases.
UNASSIGNED: Five-hundred and sixty-five human monkeypox confirmed cases were analysed; 97.2% were men, of whom 59.5% identified as men who have sex with men, and 54.5% had human immunodeficiency virus infection. The median age was 34 years. All patients but one had rash (99.8%), 78.9% had fever, and 47.8% reported myalgia. The anogenital area was the most commonly affected one by rash (49.6%), and proctitis occurred in 6.2% of patients. Six patients required hospitalization, of which one died due to causes unrelated to monkeypox.
UNASSIGNED: The 2022 monkeypox outbreak in Mexico is mainly driven by middle-aged men who have sex with men, of which a large proportion are persons who live with human immunodeficiency virus infection. Clinical features such as the high proportion of anogenital lesions suggest sexual contact is a pivotal transmission mechanism in this outbreak.
UNASSIGNED: This research was supported by grant A1-S-18342 from Consejo Nacional de Ciencia y Tecnología (CONACyT), Mexico (to S.I.V.-F.).
摘要：
未经批准：人类猴痘，西非和南非历史上特有的人畜共患病，导致由人传人引发的全球疫情，导致国际公共卫生紧急情况。地方性和爆发猴痘病例在受影响人群中可能有所不同，临床特征,和结果。因此，目前在全球范围内爆发猴痘的病例分析至关重要。
UNASSIGNED：我们于2022年5月24日至9月5日进行了一项基于全国性观察性监测的研究。通过实时聚合酶链反应对符合猴痘临床定义或确诊病例的有症状密切接触者的患者进行测试。使用标准化的病例报告表收集临床数据。我们报告流行病学，社会人口统计学，和确诊病例的临床特征。
UNASISIGNED：分析了五百六十五例猴痘确诊病例；97.2％为男性，其中59.5%的人认为是男男性行为者，54.5%有人类免疫缺陷病毒感染。中位年龄为34岁。所有患者均有皮疹（99.8%），78.9%有发烧,47.8%报告肌痛。肛门生殖器区域是最常见的皮疹（49.6％），6.2%的患者发生直肠炎。六名患者需要住院治疗，其中一人死于与猴痘无关的原因。
UNASSIGNED：墨西哥2022年的猴痘爆发主要是由与男性发生性关系的中年男人推动的，其中很大一部分是患有人类免疫缺陷病毒感染的人。临床特征，例如高比例的肛门生殖器病变，表明性接触是这次爆发的关键传播机制。
UNASSIGNED：这项研究得到了来自CienciayTecnologia（CONACyT）的A1-S-18342资助，墨西哥（至S.I.V.-F.).
UNASSIGNED：我们于2022年5月24日至9月5日进行了一项基于全国性观察性监测的研究。通过实时聚合酶链反应对符合猴痘临床定义或确诊病例的有症状密切接触者的患者进行测试。使用标准化的病例报告表收集临床数据。我们报告流行病学，社会人口统计学，和确诊病例的临床特征。
UNASISIGNED：分析了五百六十五例猴痘确诊病例；97.2％为男性，其中59.5%的人认为是男男性行为者，54.5%有人类免疫缺陷病毒感染。中位年龄为34岁。所有患者均有皮疹（99.8%），78.9%有发烧,47.8%报告肌痛。肛门生殖器区域是最常见的皮疹（49.6％），6.2%的患者发生直肠炎。六名患者需要住院治疗，其中一人死于与猴痘无关的原因。
UNASSIGNED：墨西哥2022年的猴痘爆发主要是由与男性发生性关系的中年男人推动的，其中很大一部分是患有人类免疫缺陷病毒感染的人。临床特征，例如高比例的肛门生殖器病变，表明性接触是这次爆发的关键传播机制。
UNASSIGNED：这项研究得到了来自CienciayTecnologia（CONACyT）的A1-S-18342资助，墨西哥（至S.I.V.-F.).
